Target & readout
Agree on the cargo, intended destination, receptor strategy, model, and functional success criteria.
RNA Research Solutions
RNA Products &
Targeted Delivery
Catalog RNAs, custom RNA synthesis, IVT reagents and LNP formulation for cell-based and in vivo research.
Linear mRNAsaRNATargeted LNP development
mRNA–tLNP Services
Targeted LNP
Development
Development objectives
Define the target cell or tissue, formulation approach and evaluation endpoints. Assess expression, distribution and tolerability in the selected model.
Discuss your targeting project ↗In the quote form, use Other additional requirements to describe your target cell or tissue, formulation needs, and planned readouts.
Why targeting? Systemic LNP delivery often favors the liver. Targeted-delivery research seeks to reach intended cell populations, including extrahepatic targets, and produce a measurable functional response.
01
Target cells and tissues
Specify the target cell or tissue, candidate receptor, experimental model, and administration route.
02
Expression and editing
Plan protein-expression or editing readouts alongside RNA-associated uptake measurements.
03
Selectivity and tolerability
Choose target and non-target comparisons, with relevant viability or response measurements.
Service Methods
Targeting Approaches
and Formulation
Ligand conjugation supports receptor-directed approaches. SORT uses LNP composition and component ratios to investigate organ-selective delivery.
Ligand & formulation
Plan ligand conjugation and lipid composition around RNA requirements and the targeting hypothesis.
Microfluidic assembly
Encapsulate the RNA and characterize particle size, PDI, encapsulation, and RNA content.
QC & model assessment
Review analytical results and define uptake, expression, selectivity, or editing studies with the project team.
The formulation and analytical package are agreed per project. Biological testing, execution responsibilities, and any optimization rounds are scoped separately.
Service Capabilities
RNA Synthesis, Formulation
and Analytical Support
Catalog and custom RNA
Connect catalog reporter RNAs or custom RNA synthesis with LNP development. Discuss existing cargo for project assessment.
Cell and organ targeting
Ligand conjugation and SORT formulation provide approaches for cell- and organ-targeting research.
Microfluidic encapsulation
Pair formulation with size, PDI, Zeta potential, encapsulation and loading analyses; discuss Cryo-EM requirements.
Reporter RNA tools
Use Cy5-labeled, EGFP, or luciferase reporter RNAs to design informative delivery experiments.
Research applicationsImmune-cell deliveryIn vivo cell engineeringTargeted gene editingExtrahepatic delivery
Reporter RNAs for delivery evaluation
See reporter RNA applications ↓Cy5-labeled, EGFP and luciferase RNAs with published application data.
Reporter RNA Applications
RNA Tracking
and Protein Expression
Evaluate RNA-associated uptake and localization alongside EGFP fluorescence or luciferase expression.
R1011 · Cy5 EGFP mRNAEZ Cap™ Cy5 EGFP mRNA
View product & specifications ↗
EZ Cap™ Cy5 EGFP mRNA
(5-moUTP)
A fluorescently labeled reporter RNA that connects RNA tracking with a protein-expression readout.
Cy5 · RNA-associated signalVisualize labeled RNA uptake and localization.
EGFP · Functional expressionMeasure expression of the encoded reporter.
R1010 · Cy5 Firefly Luciferase mRNAEZ Cap™ Cy5 Firefly Luciferase mRNA
View R1010 & specifications ↗
EZ Cap™ Cy5 Firefly Luciferase mRNA
(5-moUTP)
Combine fluorescent RNA tracking with a bioluminescent readout of reporter protein expression.
Cy5 · RNA-associated signalStudy labeled RNA localization and tissue distribution.
Firefly luciferase · Functional expressionMeasure reporter expression using an appropriate luciferase substrate.
Published Applications
Delivery Formulation Comparisons
Published cell and animal studies using APExBIO reporter mRNAs.
Published research applications. The studies’ LNP formulations are not presented as APExBIO service performance data.
RNA Products
Catalog RNA Products
Explore ready-to-use RNAs for delivery evaluation, protein expression, gene editing, and immune research.
FLUORESCENTLY LABELEDR1011
EZ Cap™ Cy5 EGFP mRNA
5-moUTP-modified RNA for tracking labeled RNA and EGFP expression.
View product ↗FLUORESCENT REPORTERR1016
EZ Cap™ EGFP mRNA
5-moUTP-modified EGFP mRNA for fluorescence-based expression assays.
View product ↗BIOLUMINESCENT REPORTERR1013
EZ Cap™ Firefly Luciferase mRNA
A luciferase reporter for quantitative functional-expression studies.
View product ↗FLUORESCENTLY LABELEDR1010
EZ Cap™ Cy5 Firefly Luciferase mRNA
5-moUTP-modified RNA for Cy5 tracking and luciferase-expression assays.
View product ↗BIOLUMINESCENT REPORTERR1107
Enhanced EZ Cap™ Firefly Luciferase mRNA (m1Ψ)
A modified linear reporter mRNA for protein-expression and delivery assays.
View product ↗SELF-AMPLIFYING RNAR3002
Firefly Luciferase saRNA
A self-amplifying reporter for RNA expression and delivery research.
View product ↗GENE EDITINGRESEARCH TOOLS
Cas9, Cre & editor mRNAs
Explore RNA tools for gene editing and cell engineering experiments.
View gene-editing mRNAs ↗DISEASE & IMMUNEFUNCTIONAL RNAs
Cytokine & disease-related mRNAs
Browse IL-family, OVA, p53, PTEN and other functional RNA tools.
View disease and immune mRNAs ↗SUBCELLULAR IMAGINGPROBE RNAs
Organelle probe mRNAs
Label organelles for live-cell dynamics and super-resolution imaging.
See imaging applications →Browse more RNA products
Need a different sequence, modification, or format?
Explore custom synthesis →Featured RNA Tools · Subcellular Imaging
Organelle Probe mRNAs
Label organelles from within living cells. mRNAs encode fluorescent proteins fused to organelle-localization signals, revealing subcellular structures as they change over time.
- Live-cell dynamic imaging
- Follow organelle morphology, movement and network remodeling over time.
- Super-resolution imaging
- Resolve fine ER and mitochondrial structures with HIS-SIM, demonstrated in primary cells.
- Organelle-specific, multicolor labeling
- Select ER, mitochondrial or Golgi probes; combine compatible fluorescent channels to study organelle interactions.
Explore EZ Cap™ probe mRNAs (m1Ψ)
View all organelle probe mRNAs ↗Published application data: Wang et al., FASEB J. (2024) ↗. Images: wen yang, Mendeley Data, v2 ↗, CC BY 4.0. Original channels retained; dynamic snapshots arranged as a montage. These study constructs illustrate the imaging approach, rather than validation of each listed SKU. Resolution depends on the imaging system and acquisition conditions.
RNA Synthesis Services
Custom RNA Synthesis
Template preparation, RNA synthesis and purification, with optional LNP encapsulation and project-defined quality control.
01
Sequence & template
Discuss sequence requirements and DNA template preparation.
02
RNA synthesis
Define the RNA format, capping and modification strategy.
03
Purification
Select the purification approach for your construct.
04
LNP encapsulation
Add formulation and characterization to the project.
Optional05
QC & delivery
Receive RNA or formulation with agreed documentation.
Choose your RNA formatLinear mRNASelf-amplifying RNA
Request custom RNA synthesis ↗Choose an RNA type and indicate whether you need LNP coating in the quote form.
Quality control matched to your RNA and project +
Discuss RNA concentration, integrity, purity, capping efficiency, poly(A) characterization and additional testing appropriate to your construct. Included and optional tests are defined in the project scope.
Reagents and Kits
RNA Raw Materials
IVT synthesis and labeling kits, enzymes, modified nucleotides, purification reagents and LNP components.
PREPARE YOUR STARTING MATERIAL
DNA template preparation
Explore amplification and template-processing reagents for your RNA synthesis workflow.
Browse IVT reagentsSelected GMP-grade Materials
GMP-grade RNA Synthesis Reagents
Explore selected capping reagents, nucleotides, and enzymes. Grade and documentation apply to the specified product.
Product FAQs
Frequently Asked Questions
Practical answers from our product pages: RNA selection, modifications, handling, expression and purification.
Ask our technical team ↗01How do I choose an RNA product?
Choose EGFP or firefly luciferase mRNA to evaluate delivery and expression. Use functional mRNAs such as p53, PTEN, cytokines, Cas9 or Cre for biological studies. Consider saRNA for sustained-expression studies.
Product FAQ · R1010 / Q1 ↗02Which RNA modification fits my application?
m1Ψ, ψUTP and 5-moUTP help modulate immunogenicity, stability and translation. Choose Cy5-UTP or biotin labeling for RNA tracking, localization and detection.
Product FAQ · R1010 / Q5 ↗03How should I handle RNA?
Thaw on ice, gently centrifuge, aliquot and avoid repeated freeze–thaw cycles. Use RNase-free reagents and consumables. Mix RNA with transfection reagent before adding it to serum-containing medium.
Product FAQ · R1010 / Q6 ↗04How can I troubleshoot low protein expression?
Check storage, freeze–thaw history and RNase contamination. Use reporter mRNA as a positive control. Optimize the RNA-to-reagent ratio, cell density, incubation time and detection time point.
Product FAQ · R1010 / Q7 ↗05How can I purify RNA after in vitro transcription?
Use the RNA Clean and Concentrator Kit (K1069). For poly(A)-tailed mRNA, use oligo(dT) beads or the mRNA Magnetic Purification Kit (K1307).
Product FAQ · K1401 / Q6 ↗Product and Service Inquiries
Contact APExBIO
Start with a reporter RNA or discuss a custom RNA and delivery project.