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Apoptosis

Apoptosis, also known as programmed cell death, is rigorously controlled process of cell death that leads to phagocytosis of unwanted cell. It is triggered after sufficient cellular damage and activated through extrinsic or intrinsic pathways. The intrinsic pathway is mainly occurs via release of cytochrome c from the mitochondria and regulates mitochondrial outer membrane permeabilization by Bcl-2 family proteins. The extrinsic pathway is induced by ligand binding to death receptor, such as Fas, TNFαR, DR3, DR4, and DR5. Caspases then cleave target proteins and nuclear lamins to promote DNA degradation, resulting apoptotic cells undergo phagocytosis. In addition, p53 has the ability to activate intrinsic and extrinsic pathways of apoptosis by inducing transcription of several proteins like Puma, Bid, Bax, TRAIL-R2, and CD95.

Some Inhibitors of apoptosis proteins (IAPs), such as XIAP/BIRC4 and Bruce/BIRC6, can block casapse activity through direct binding, while other IAPs, such as cIAP1/BIRC2, cIAP2/BIRC3, act as ubiquitin ligases that target caspases for ubiquitin-mediated degradation. Apoptosis is essential for growth, development and aging in multicellular organisms. Any alterations or abnormalities occurring in apoptotic processes contribute to development of human diseases, including cancer.

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  1. VU661013
    Catalog No. :
    A8783
    Novel, potent, selective MCL-1 inhibitor

    VU661013 is a novel, potent, selective MCL-1 inhibitor (Ki of 97 ± 30 pM).

  2. PD-1/PD-L1 inhibitor 2
    Catalog No. :
    B6023
    PD-1/PD-L1 interaction inhibitor
  3. Z-VAD-FMK
    Catalog No. :
    A1902
    Cell-permeable, irreversible pan-caspase inhibitor

    Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

  4. 7BIO
    Catalog No. :
    C5685
    caspase independent nonapoptotic cell death inducer
  5. Se-Aspirin
    Catalog No. :
    C5667
    nonsteroidal anti-inflammatory drug
  6. F16
    Catalog No. :
    C5565
    potential antitumor agent
  7. NK 252
    Catalog No. :
    C5715
    Nrf2 activator
  8. ML-291
    Catalog No. :
    C5358
    apoptosis inducer
  9. Z-Asp-CH2-DCB
    Catalog No. :
    C4981
    caspase inhibitor
  10. Psoralidin
    Catalog No. :
    C4962
    apoptosis inducer

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