Toggle Nav

Bax

BAX (the BCL-2-associated X protein), a cardinal pro-apoptotic member of the BCL-2 family, is a latent, cytosolic and monomeric protein that plays an important role in the mitochondria-dependent apoptotic pathway. The nuclear magnetic resonance (NMR) spectroscopic analysis suggests that the structure of Bax consists of nine α-helices (α1 to α9) connected by short loops, in which α5, α6 and α9 are involved in the interaction of Bax with outer mitochondrial membrane (OMM). Bax remains inactive in cytosol and goes through conformational changes triggered by a cell death signal to insert, oligomerize and form large pores through the OMM with the releasing of different apoptogenic factors.

7 Items

per page
  1. PRIMA-1MET
    Catalog No. :
    A4484
    Restore mutant p53 activity, induce BAX and PUMA

    PRIMA-1MET selectively restores the activity of mutant p53 in tumor cells.[1]

  2. PRIMA-1
    Catalog No. :
    A4483
    BAX inhibitor
    Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human tumors with mutant p53.
  3. Bax inhibitor peptide, negative control
    Catalog No. :
    A4462
    Peptide inhibit Bax translocation to mitochondria
    Negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
  4. Bax inhibitor peptide V5
    Catalog No. :
    A4461
    Bax inhibitor
    Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
  5. Bax inhibitor peptide P5
    Catalog No. :
    A4460
    Bax inhibitor
    Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
  6. Bax channel blocker
    Catalog No. :
    A4459
    Inhibitor of Bax-mediated mitochondrial cytochrome c release
    Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.
  7. BAM7
    Catalog No. :
    A3218
    BAX activator,direct and selective
    BAM7 is a direct and selective activator of BAX with IC50 value of 3.3uM .

7 Items

per page