PRIMA-1
Catalog No.
A4483
BAX inhibitor
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PRIMA-1 (CAS: 5608-24-2) is a small molecule that restores the tumor suppressor function of mutant p53 proteins, which are frequently overexpressed in various tumor types. PRIMA-1 reactivates the transcriptional activity of mutant p53 and induces apoptosis in cancer cells. In vitro studies show that treatment of Saos-2-His-273 cells with PRIMA-1 results in apoptosis-driven cell death, with an IC50 exceeding 15 μM. In vivo, administration of PRIMA-1 reduces tumor volumes in mouse models bearing mutant p53-expressing xenografts. PRIMA-1 is widely utilized in preclinical research to investigate strategies targeting mutant p53 for cancer therapy.
References:
[1] Neff T, Blau CA. Pharmacologically regulated cell therapy. Blood. 2001 May
1;97(9):2535-40.| Physical Appearance | A solid |
| Storage | Store at 4°C |
| M.Wt | 185.22 |
| Cas No. | 5608-24-2 |
| Formula | C9H15NO3 |
| Solubility | ≥110.6 mg/mL in H2O; ≥16.3 mg/mL in EtOH with ultrasonic; ≥9.1 mg/mL in DMSO |
| Chemical Name | 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
| SDF | Download SDF |
| Canonical SMILES | OCC1(CO)N(CC2)CCC2C1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | PRIMA-1 is an inhibitor of cell-permeable BAX. | |||||
| Targets | p53 | |||||
| IC50 | ||||||
Quality Control & MSDS
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