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DNA Alkylating

DNA alkylating is the transfer of alkyl groups to particular bases, resulting in alkylation products such as O2‐alkylthymine and O6‐methylguanine that lead to DNA mutations.

9 Items

per page
  1. Altretamine
    A2559 Altretamine
    Summary: Antineoplastic agent
      insoluble in H2O; ≥36.3 mg/mL
  2. Busulfan
    A8386 Busulfan
    Summary: DNA alkylating agent
      ≥12.3 mg/mL
  3. Lomustine
    B1963 Lomustine
     1 Citation
    Target: RNA synthesis
    Summary: Antineoplastic drug
      insoluble in H2O; ≥23.41 mg/mL
  4. Trioxsalen
    C4451 Trioxsalen
    Summary: intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light
  5. Illudin S
    C4732 Illudin S
    Summary: potent antitumor sesquiterpene
      Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
  6. Temozolomide
    B1399 Temozolomide
    Summary: small-molecule alkylating agent and DNA damage inducer
      insoluble in EtOH; insoluble in H2O; ≥29.61 mg/mL
  7. Carmustine
    B3489 Carmustine
    Summary: cell-cycle phase nonspecific alkylating antineoplastic agent
      insoluble in H2O; ≥21.51 mg/mL
  8. Thio-TEPA
    B3742 Thio-TEPA
    Summary: alkylating agent used to treat cancer
  9. Palifosfamide
    A3696 Palifosfamide
    Summary: Active metabolite of ifosfamide (IFOS)
      ≥22.1 mg/mL

9 Items

per page