ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.
- Netarsudil (AR-13324)Catalog No. :B7807ROCK inhibitor
- LX7101 HCLCatalog No. :B5863Dual LIM-kinase and ROCK inhibitor
- GSK269962ACatalog No. :B3392ROCK inhibitorGSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.
- SR-3677Catalog No. :B1294Rho Kinase (ROCK-II) inhibitorSR-3677 is a novel, potent and highly selective inhibitor of Rho Kinase (ROCK-II) with the IC50 value of ~0.3nM in enzyme and cell based assays .
- Y-27632Catalog No. :B1293ROCK inhibitor,potent and selectiveY-27632 is a specific inhibitor of Rho-associated kinases(ROCK) family with Ki values of 0.22μM and 0.30μM for ROCK1 and ROCK2, respectively.
- Y-39983 dihydrochlorideCatalog No. :B1176ROCK family inhibitorY-39983 dihydrochloride is a novel and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK .
- Fasudil (HA-1077) HClCatalog No. :A5734Protein kinase inhibitorCyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
- GSK429286ACatalog No. :A5611Selective ROCK1/ROCK2 inhibitorSelective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively).
- ThiazovivinCatalog No. :A5506ROCK inhibitorGreatly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 and PD 0325901.
- SLx-2119Catalog No. :A3825Selective ROCK2 inhibitor
SLx-2119(KD-025) is a selective inhibitor of ROCK2 with IC50 of 105 nM .