TGF-β / Smad Signaling

The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.
-
B5946 EW-71971 CitationTarget: BMP and Other Activin ReceptorsSummary: Selective inhibitor of TGF-β type I receptor kinase -
B5858 ITD 1Summary: The first selective TGFβ inhibitor -
B4965 (-)-epicatechin gallateSummary: major catechin in green tea -
B4964 (-)-epicatechinSummary: inducer of pancreatic β-cell regeneration -
B8775 R162 -
B8451 BAY1895344 -
B7785 LDN 209929 dihydrochlorideTarget: haspin kinaseSummary: haspin kinase inhibitor -
A9036 Hydronidone -
C5388 Hexadecyl Methyl GlycerolSummary: protein kinase C activity inhibitor -
C4885 1,2-Dimyristoyl-sn-glycerol
