R1010
EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP)
- Cy5 fluorescence: RNA tracking Far-red signal
- Luciferase bioluminescence: protein expression Requires luciferase substrate
About APExBIO
Research tools for discovery, from small molecules to RNA.
APExBIO supplies research reagents for life science and drug discovery, bringing together bioactive compounds, screening libraries, RNA products, and tools for molecular and cellular experiments.
Supporting research into biological mechanisms, RNA delivery and expression, and experimental outcomes.
- Publications
- 20,000+
- Active SKUs
- 27,000+
- Countries & regions served
- 70+
Reporter mRNA spotlight
Follow the RNA.
Measure the expression.
Fluorescently labeled reporter mRNAs pair an RNA tracking signal with a protein expression readout, helping researchers examine RNA uptake and reporter expression as distinct experimental readouts.
Explore RNA research solutions
R1011
EZ Cap™ Cy5 EGFP mRNA (5-moUTP)
- Cy5 fluorescence: RNA tracking Far-red signal
- EGFP fluorescence: protein expression Requires excitation light
Research in practice
Selected research in leading journals
See how researchers use APExBIO reagents in RNA delivery, mechanism studies and structural biology.
RNA delivery & expression
Nature Biotechnology · 2026
Connecting LNP structure with RNA delivery
Researchers used APExBIO Cy5-labeled GFP mRNA to distinguish RNA uptake from protein expression in primary T cells.
Read the LNP studyStudy & product details
Elucidating lipid nanoparticle properties and structure through biophysical analyses
DOI: 10.1038/s41587-025-02855-x
The Materials section identifies APExBIO Cy5-tagged GFP mRNA with 5moU substitutions. Figure 6h–n distinguishes RNA uptake from GFP expression in primary human T cells.
The paper does not state a catalog number. R1011 is shown as a related product, not a confirmed catalog-number citation.
Materials · author-hosted paper, p. 15Author correction · January 2026
Nature Communications · 2026
Examining endosomal escape
Researchers used APExBIO Cy5-labeled luciferase reporter mRNA in HepG2 cells to assess endolysosomal escape by fluorescence colocalization.
Read the studyStudy & product details
Antioxidant malic-acid-derived lipid nanoparticles delivering secretory uricase circRNA for hyperuricemia and complication management in mice
DOI: 10.1038/s41467-026-73544-9
The Materials section names APExBIO EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP). Cy5-mRNA was used to assess endolysosomal escape by fluorescence colocalization in HepG2 cells (Fig. 3a–b). This reporter is distinct from the therapeutic uricase circRNA.
The complete product name matches R1010; the paper does not print the catalog number.
Read the original article
Science · 2026
RNA synthesis for a preclinical cardiac study
APExBIO modified nucleotides were used to synthesize RNA for research in mouse and swine models of myocardial infarction.
5-Methyl-CTP · B7967 / Pseudo-UTP · B7972
Read the studyStudy & product details
Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction
The RNA design and synthesis methods identify APExBIO B7967 and B7972 as modified nucleotides used in in vitro transcription.
Read the open-access manuscriptCell · 2025
Dissecting cell death mechanisms
APExBIO Z-VAD-FMK and other small molecules helped investigate cell death following loss of RNA polymerase II.
Z-VAD-FMK · A1902
Read the studyStudy & product details
RNA Pol II inhibition activates cell death independently from the loss of transcription
DOI: 10.1016/j.cell.2025.07.034
The Key resources table identifies APExBIO z-VAD-FMK, Cat. A1902. The study used caspase inhibition to investigate cell death after RNA polymerase II loss.
Read the open-access manuscriptNature · 2026
Preparing protein complexes for structural biology
APExBIO FLAG peptide was used to elute protein complexes for a study of regulated N-glycosylation.
3X FLAG Peptide · A6001
Read the studyStudy & product details
Structural basis of regulated N-glycosylation at the secretory translocon
DOI: 10.1038/s41586-025-09756-8
Sample preparation for cryo-EM identifies FLAG peptide from APExBIO, A6001, for eluting protein complexes. A6001 is the 3X FLAG peptide product, also listed as 3X (DYKDDDDK) Peptide.
Read the open-access articleScientific illustrations are schematic. See the linked papers for experimental figures.
A portfolio built around experimental questions
RNA synthesis, delivery and expression
Reporter mRNAs, circular RNA, self-amplifying RNA, modified nucleotides, and reagents for RNA preparation and analysis.
Small molecules & screening
Inhibitors, activators and compound libraries for target and pathway research.
ABT-263 · Y-27632 · DiscoveryProbe™ libraries
Molecular & cell assays
Reagents for cell viability, nucleic acid staining and qPCR.
CCK-8 · Safe DNA Gel Stain · qPCR reagents
Protein research
Tools for purification, sample preparation and protein analysis.
3X FLAG Peptide · Protease inhibitors · Phosbind
Information that supports product selection
Review product specifications, available analytical and functional data, and the relevant Certificate of Analysis when evaluating a reagent.
Our team can help you locate documentation and discuss product selection or use.
Specifications
Product details and use information.
Available data
Analytical and functional data
(where available).
Certificates of Analysis
Batch-specific information
(where available).
Let’s discuss your next experiment.
Tell us about your application and the information you need.