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Pseudo-UTP

Catalog No.
B7972
A modified nucleoside-5’-O-triphosphate, commonly used for drugable mRNA synthesis
Grouped product items
SizePriceStock Qty
10ul (100 mM)
$51.00
In stock
50ul (100 mM)
$235.00
In stock
100ul (100 mM)
$402.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Pseudo-UTP, also known as pseudouridine-5’-O-triphosphate, is one of the most commonly used modified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building block for the polymerase-mediated synthesis of RNA molecules. RNA molecules, especially messenger RNAs (mRNAs), have widespread applications in therapeutic and diagnostic areas, and have demonstrated their superiority over plasmid DNA techniques in both gene and vaccination therapy. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties. Thus, pseudo-UTP could be used to develop drugable mRNAs with improved properties, by replacing the standard bases by modified ones. 

Reference:

1. Shanmugasundaram M, Senthilvelan A, Kore AR. Gram-scale chemical synthesis of base-modified ribonucleoside-5'-O-triphosphates. Current Protocols in Nucleic Acid Chemistry, 2016, 67: 13.15.1-13.15.10.

Product Citation

Chemical Properties

Physical AppearanceSolution
StorageStore at -20°C or below
M.Wt484.1 (free acid)
FormulaC9H15N2O15P3 (free acid)
SynonymsPseudouridine-5'-Triphosphate, 5-Ribosyl Uracil
Chemical Namelithium (5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate
SDFDownload SDF
Canonical SMILESO=C(NC=C1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+]
Shipping ConditionShip with blue ice, or upon other requests.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Pseudo-UTP

Related Biological Data

Pseudo-UTP