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Other Apoptosis

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  1. UC 112
    Catalog No. :
    B7790
    IAP inhibitor
    IAP inhibitor (IC50 values from 0.7 - 3.4 μM); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.
  2. Necrosulfonamide
    Catalog No. :
    B7731
    Necroptosis inhibitor

    New Product

  3. TLQP 21
    Catalog No. :
    A4475
    VGF-derived peptide
    VGF-derived peptide; spans residues 556-576 of the precursor sequence. Protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. Increases energy expenditure and prevents early phase diet-induced diabetes.
  4. Melphalan
    Catalog No. :
    A4473
    DNA alkylating agent
    DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μM for sequential dosing and single dosing respectively).
  5. Mdivi 1
    Catalog No. :
    A4472
    Selective DRP1/Dnm1 inhibitor, cell-permeable

    Selective inhibitor of Dnm1 GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis.

  6. GRI 977143
    Catalog No. :
    A4471
    LPA2 receptor non-lipid agonist
    Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.
  7. DAPK Substrate Peptide
    Catalog No. :
    A4469
    Synthetic peptide substrate for DAPK
    Synthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 μM).
  8. Cesium chloride
    Catalog No. :
    A4468
    Potassium channel blocker
    Potassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β.

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