17,20-lyase, also known as CYP17A1, is a monooxygenase that catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
- TAK-700 R-formCatalog No. :B119417, 20-lyase inhibitorTAK-700 R-form is a highly selective inhibitor of 17, 20-lyase with IC50 value of 38nM .
- TAK-700 saltCatalog No. :A3852Androgen synthesis inhibitorTAK-700 salt
- OrteronelCatalog No. :A3686For castration-resistant prostate cancer, clinical candidateIC50: Orteronel inhibited monkey 17,20-lyase and 17-hydroxylase activities with IC50 values of 27 and 38 nmol/L, respectively