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Bioactive Compounds
Signaling Pathways
Protein Tyrosine Kinase/RTK

Protein Tyrosine Kinase/RTK

C8982 Pirtobrutinib (LOXO-305)

Summary: Pirtobrutinib (LOXO-305) is a highly selective, non-covalent Bruton's tyrosine kinase inhibitor targeting B-cell receptor signaling, widely utilized in hematologic malignancy research.
C8979 Pralsetinib (BLU-667)

Summary: Pralsetinib (BLU-667; CAS 2097132-94-8) is a selective RET tyrosine kinase inhibitor targeting RET signaling, widely utilized in oncology and molecular signaling research.
C8976 Avapritinib (BLU-285)

Summary: Avapritinib (BLU-285; CAS 1703793-34-3) is a selective KIT and PDGFRA tyrosine kinase inhibitor widely utilized in oncology and signal transduction research.
C8921 Ripretinib (DCC-2618)

Summary: Ripretinib (DCC-2618; CAS 1442472-39-0) is a switch-control tyrosine kinase inhibitor targeting KIT and PDGFRA, widely used in oncology and kinase-signaling research.
C8918 Ritlecitinib (PF-06651600)

Summary: Ritlecitinib (PF-06651600; CAS 1792180-81-4) is a selective covalent JAK3/TEC family kinase inhibitor used to investigate cytokine signaling and immune-cell pathway biology.
C8917 Tucatinib

Summary: Tucatinib is a selective small-molecule HER2 tyrosine kinase inhibitor targeting ERBB2 signaling, widely utilized as a chemical probe in oncology and signal transduction research.
C8914 Fursultiamine

Summary: Fursultiamine is a lipophilic thiamine derivative used to investigate vitamin B1 metabolism, thiamine-dependent enzymatic pathways, and cellular bioenergetics in biochemical research.
C8890 Levomilnacipran Hydrochloride

Summary: Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor targeting monoamine transporters, widely utilized in neuropharmacology and neurotransmission mechanism research.
C8845 Xanthinol Nicotinate

Summary: Xanthinol nicotinate is a vasoactive nicotinic acid ester modulating purinergic signaling and microcirculatory dynamics, utilized in cardiovascular physiology and cellular metabolism research.
M1303 caprate (10:0)

Summary: A fatty acid with anti-epileptic activity and the ability to inhibit liver cancer cells.