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Biochemical Reagent
Signaling pathways
Apoptosis/Autophagy

Apoptosis/Autophagy

B5854 Pexidartinib (PLX3397)
3 Citation

Target: FLT3|c-Kit|CSF1R

Summary: A multi-targeted receptor tyrosine kinase inhibitor; A CSF-1R inhibitor

insoluble in EtOH; insoluble in H2O; ≥20.9 mg/mL
A1915 Zebularine
1 Citation

Target: DNA Methyltransferases|Cytidine deaminases

Summary: Cytidine analog; DNA methyltransferase (DNMT) inhibitor; induces DNA demethylation

insoluble in EtOH; ≥50.7 mg/mL
A4099 Valproic acid sodium salt

Target: Histone Deacetylases (HDACs)

Summary: A class I HDAC inhibitor

≥8.35 mg/mL
BA2003 U0126

Summary: A potent, non-ATP-competitive, selective MEK inhibitor

≥23.15 mg/mL
A8253 PD 173074
5 Citation

Target: VEGFR|FGFR

Summary: FGFR inhibitor

≥26.18 mg/mL
A3335 Curcumin
1 Citation

Target: Histone Deacetylases (HDACs)|Nrf2|Histone Acetyltransferases (HATs)|Tyrosinases

Summary: Specific histone and non-histone acetyltransferase inhibitor

≥36.8 mg/mL
B4799 Telaglenastat
1 Citation

Target: Glutaminases

Summary: Orally active glutaminase inhibitor

≥28.6 mg/mL
B8205 Dextran sulfate sodium salt (MW 35000-45000)

Summary: Nucleic acid hybridization enhancer; for acute or chronic colitis models

insoluble in EtOH; insoluble in DMSO; ≥55.5 mg/mL
A8463 Lithocholic Acid

Target: Farnesoid X receptors (FXRs)|Vitamin D receptors (VDRs)|Pregnane X receptor(PXR)

Summary: Toxic secondary bile acid; induces intrahepatic cholestasis; FXR antagonist and PXR/SXR agonist

insoluble in H2O; ≥12.95 mg/mL
B5965 Tamoxifen
17 Citation

Target: PKC

Summary: estrogen receptor modulator

≥18.6 mg/mL