Membrane Transporter/Ion Channel

Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.
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C8598 TPMPA (hydrate)Summary: TPMPA is a selective competitive antagonist for GABAA-ρ (also known as GABAC) receptors, particularly showing selectivity for the ρ1 subtype over ρ2. -
B6071 SpadinSummary: TREK-1 channel inhibitor -
C6638 Idramantone -
B8903 TGN-020 -
B8792 GsMTx4 TFA -
B6070 Spadin TFA -
B4951 Chlorothiazide SodiumSummary: diuretic and antihypertensive -
B4663 XEN445Summary: Endothelial lipase(EL) inhibitor -
B2056 TrichlormethiazideSummary: thiazide diuretic -
B2055 TorsemideSummary: pyridine-sulfonyl urea type loop diuretic
