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Suramin hexasodium salt

Catalog No.
B6752
DNA topoisomerase II inhibitor
Grouped product items
SizePriceStock Qty
5mg
$65.00
In stock
10mg
$95.00
In stock
25mg
$165.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

Suramin hexasodium salt (CAS 129-46-4) is a polysulfonated naphthylurea derivative that competitively inhibits DNA topoisomerase II, an enzyme essential for managing DNA supercoiling and topology during replication and transcription, with an IC50 of approximately 5 μM. Suramin selectively inhibits cellular DNA synthesis and proliferation, notably blocking SV40 DNA replication entirely at a concentration of 40 μM in HeLa cells. The compound demonstrates differential inhibitory effects towards DNA polymerases α and δ (IC50 of 8 μM and 36 μM, respectively). Additionally, suramin significantly inhibits bacterial RecA-mediated ATPase activity, strand exchange processes, and proteolytic cleavage of the LexA transcriptional repressor. In preclinical models of pulmonary hypertension, suramin reduces vascular remodeling, inflammation, and pulmonary artery pressure, reflecting its utility in cellular proliferation, enzyme function, and disease model research.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt1429.15
Cas No.129-46-4
FormulaC51H34N6Na6O23S6
Solubility≥71.45 mg/mL in H2O; insoluble in EtOH; ≥21 mg/mL in DMSO
Chemical Namesodium 8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonate)
SDFDownload SDF
Canonical SMILES[O-]S(=O)(C1=C(C(NC(C2=CC=C(C)C(NC(C3=CC=CC(NC(NC4=CC(C(NC5=CC(C(NC(C(C6=CC(S([O-])(=O)=O)=C7)=C7S([O-])(=O)=O)=CC=C6S([O-])(=O)=O)=O)=CC=C5C)=O)=CC=C4)=O)=C3)=O)=C2)=O)=CC=C8S([O-])(=O)=O)C8=CC(S([O-])(=O)=O)=C1)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Suramin hexasodium salt