Suramin hexasodium salt
Suramin hexasodium salt (CAS 129-46-4) is a polysulfonated naphthylurea derivative that competitively inhibits DNA topoisomerase II, an enzyme essential for managing DNA supercoiling and topology during replication and transcription, with an IC50 of approximately 5 μM. Suramin selectively inhibits cellular DNA synthesis and proliferation, notably blocking SV40 DNA replication entirely at a concentration of 40 μM in HeLa cells. The compound demonstrates differential inhibitory effects towards DNA polymerases α and δ (IC50 of 8 μM and 36 μM, respectively). Additionally, suramin significantly inhibits bacterial RecA-mediated ATPase activity, strand exchange processes, and proteolytic cleavage of the LexA transcriptional repressor. In preclinical models of pulmonary hypertension, suramin reduces vascular remodeling, inflammation, and pulmonary artery pressure, reflecting its utility in cellular proliferation, enzyme function, and disease model research.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 1429.15 |
| Cas No. | 129-46-4 |
| Formula | C51H34N6Na6O23S6 |
| Solubility | ≥71.45 mg/mL in H2O; insoluble in EtOH; ≥21 mg/mL in DMSO |
| Chemical Name | sodium 8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonate) |
| SDF | Download SDF |
| Canonical SMILES | [O-]S(=O)(C1=C(C(NC(C2=CC=C(C)C(NC(C3=CC=CC(NC(NC4=CC(C(NC5=CC(C(NC(C(C6=CC(S([O-])(=O)=O)=C7)=C7S([O-])(=O)=O)=CC=C6S([O-])(=O)=O)=O)=CC=C5C)=O)=CC=C4)=O)=C3)=O)=C2)=O)=CC=C8S([O-])(=O)=O)C8=CC(S([O-])(=O)=O)=C1)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
