Suramin hexasodium salt
Suramin hexasodium salt (CAS 129-46-4) is a polysulfonated naphthylurea compound functioning primarily as a competitive inhibitor of DNA topoisomerase II (IC50 = 5 μM). DNA topoisomerase II activity is essential for managing DNA topology during replication and transcription processes. Suramin inhibits cellular proliferation and DNA synthesis in vitro, notably reducing HeLa cell DNA polymerase α (IC50 = 8 μM) and polymerase δ (IC50 = 36 μM) activities, while completely inhibiting SV40 virus DNA replication at 40 μM. Additionally, suramin suppresses bacterial RecA-mediated DNA strand exchange and ATPase activities, affecting bacterial DNA repair mechanisms. It has also shown inhibitory effects on pulmonary artery smooth muscle cell proliferation during experimental pulmonary hypertension studies.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 1429.15 |
| Cas No. | 129-46-4 |
| Formula | C51H34N6Na6O23S6 |
| Solubility | ≥71.45 mg/mL in H2O; insoluble in EtOH; ≥21 mg/mL in DMSO |
| Chemical Name | sodium 8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonate) |
| SDF | Download SDF |
| Canonical SMILES | [O-]S(=O)(C1=C(C(NC(C2=CC=C(C)C(NC(C3=CC=CC(NC(NC4=CC(C(NC5=CC(C(NC(C(C6=CC(S([O-])(=O)=O)=C7)=C7S([O-])(=O)=O)=CC=C6S([O-])(=O)=O)=O)=CC=C5C)=O)=CC=C4)=O)=C3)=O)=C2)=O)=CC=C8S([O-])(=O)=O)C8=CC(S([O-])(=O)=O)=C1)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
