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RNA Polymerase

RNA polymerase (RNAP), also known as DNA-dependent RNA polymerase, is a large and complex enzyme of several polypeptide chain subunits that catalyzes the synthesis of all cellular RNA specifically on intact DNA templates. A complete RNAP (holoenzyme) must contain two functional parts, a sigma factor (σ) and a core enzyme consisting of one beta prime subunit (β’), one beta subunit (β) and two alpha subunits (α), where the core enzyme catalyzes RNA synthesis initiated by the sigma factor at specific sites. Moreover, a growing list of factors of RNAP, including M, CAP, psi and rho, are required for the transcription reaction.

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  1. TC-E 5001
    Catalog No. :
    B5798
    dual tankyrase (TNKS) inhibitor
    New Product
  2. α-Amanitin
    Catalog No. :
    A4548
    Inhibitor of RNA polymerase II.

    Inhibitor of RNA polymerase II.

  3. Thiolutin
    Catalog No. :
    A4547
    RNA polymerase inhibitor,antibiotic

    Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.

  4. Mithramycin A
    Catalog No. :
    A4546
    Anticancer antibiotic
    Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

4 Items

per page