Bcl-xL
BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.
- A8634 WEHI-539 hydrochloride1 CitationSummary: Bcl-xL inhibitor,high affinity and selective
- B6163 A-11554632 CitationSummary: BCL-XL inhibitor, potent and selective
- B6164 A-1331852Summary: BCL-XL inhibitor, potent and selective
- A8168 HA14-1Target: Bcl-2Summary: Bcl-2 inhibitor,potent and cell-permeable
- A8193 ABT-73714 CitationSummary: Bcl-2 inhibitor
- A4234 TW-371 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
- A3424 Gambogic AcidSummary: Caspase activator and apoptosis inducer
- A3935 WEHI-53915 CitationTarget: Bcl-xlSummary: Bcl-xL inhibitor,potent and selective