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DNA Methyltransferase

DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.

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  1. 2',3',5'-triacetyl-5-Azacytidine
    Catalog No. :
    prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
  2. Nanaomycin C
    Catalog No. :
    Amide of nanaomycin A
    Nanaomycin C
  3. Nanaomycin A
    Catalog No. :
    DNMT3B inhibitor

    Nanaomycin A is a selective inhibitor of DNA methyltransferase 3B (DNMT3B) with IC50 value of 500 nM .

  4. Zebularine
    Catalog No. :
    DNA methylation inhibitor

    Zebularine, a chemically stable cytidine analog containing a 2-(1H)-pyridimidinone ring, is an effective DNA methylation inhibitor which can act with DNA methyltransferases to form a covalent complex. It has been shown to cause demethylation and reactivation of a silenced and hypermethylated p16 gene.

  5. RG 108
    Catalog No. :
    DNA methyltransferase inhibitor

    RG108 is a DNA methyltransferase (DMNT) inhibitor that enhanced reprogramming of OK-transduced MEFs in the presence of BIX.

  6. Lomeguatrib
    Catalog No. :
    MGMT inhibitor
    Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells);
  7. 5-Azacytidine
    Catalog No. :
    DNA methyltransferase inhibitor.

    5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively .

  8. Decitabine (NSC127716, 5AZA-CdR)
    Catalog No. :
    Deoxycytidine analog and cellular diifferentiation inducer

    Decitabine is a kind of deoxycytidine analog and an inducer of cellular differentiation.

  9. Thioguanine
    Catalog No. :
    Purine antimetabolite
    Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

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