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Metabolism

Glucose metabolism plays a significant role in cell proliferation, growth, survival, and tumorgenesis. Hormones such as insulin regulate the maintenance of glucose homeostasis. Insulin binding to the insulin receptor (IR) activates the insulin receptor substrate (IRS) protein, followed by the activation of PI3K/Akt and Erk1/2 signaling pathways, leads to the translocation of Glut4 vesicles, glucose uptake, cell proliferation and survival. Abnormal insulin signaling is implicated in diabetes, obesity, atherosclerosis and neurodegenerative disease etc.

Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.

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  1. Liproxstatin-1 HCl
    Catalog No. :
    B8221
    A potent ferroptosis inhibitor

    Liproxstatin-1 HCl is a potent inhibitor of ferroptosis with IC50 value of 22 nM [1].

  2. Isosafrole
    Catalog No. :
    A8703
    A stiripentol analog, a potent LDH inhibitor.
    Isosafrole, a stiripentol analog, is a potent LDH inhibitor.
  3. Stiripentol
    Catalog No. :
    A8704
    An LDH inhibitor
    Stiripentol is an LDH inhibitor
  4. (-)-p-Bromotetramisole Oxalate
    Catalog No. :
    B4750
    ALP inhibitor, potent and non-specific

    (-)-p-Bromotetramisole Oxalate (L-(-)-p-Bromotetramisole Oxalate, L-p-Bromotetramisole Oxalate, (-)-4-Bromotetramisole Oxalate) is a potent and non-specific inhibitor of alkaline phosphatase and is also an inhibitor of protein tyrosine phosphatases [1] [2].

  5. N,N'-Dicyclohexylurea
    Catalog No. :
    C3458
    soluble epoxide hydrolase (sEH) inhibitor
  6. Oleyl Trifluoromethyl Ketone
    Catalog No. :
    C5719
    potent inhibitor of FAAH
  7. 5,8,11-Eicosatriynoic Acid
    Catalog No. :
    C5811
    nonselective inhibitor of lipoxygenases (12-LO)
  8. Cycloguanil (hydrochloride)
    Catalog No. :
    C5763
    inhibitor of dihydrofolate reductase (DHFR)
  9. ST638
    Catalog No. :
    C5678
    tyrosine kinase inhibitor and PLD inhibitor
  10. RB394
    Catalog No. :
    C5671
    dual modulator of soluble epoxide hydrolase (sEH) and PPARγ

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