Glucose metabolism plays a significant role in cell proliferation, growth, survival, and tumorgenesis. Hormones such as insulin regulate the maintenance of glucose homeostasis. Insulin binding to the insulin receptor (IR) activates the insulin receptor substrate (IRS) protein, followed by the activation of PI3K/Akt and Erk1/2 signaling pathways, leads to the translocation of Glut4 vesicles, glucose uptake, cell proliferation and survival. Abnormal insulin signaling is implicated in diabetes, obesity, atherosclerosis and neurodegenerative disease etc.
Serine/threonine kinase AMPK upregulates glucose uptake by promoting the expression and function of glucose transporters. AMPK is activated by increased AMP/ATP ratio, resulting from cellular and environmental stress, e.g. low glucose, heat shock, hypoxia and ischemia. AMPK activation positively modulates signaling transductions that refill ATP levels. Moreover, it also stimulates catabolic processes such as fatty acid oxidation and glycolysis through inhibition of ACC and activation of PFK2. AMPK negatively regulates various proteins which are important to ATP-consuming mechanisms, e.g. mTORC2, glycogen synthase, SREBP-1, and TSC2, causing the downregulation/inhibition of gluconeogenesis and glycogen, lipid and protein synthesis.
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- B8354 PapainSummary: A cysteine protease of the peptidase C1 family
- B8221 Liproxstatin-1 HClSummary: A potent ferroptosis inhibitor
- B7911 Pyridoxal hydrochlorideSummary: An endogenous metabolite
- B7904 N-acetyl D-galactosamineSummary: An endogenous metabolite
- B7888 Glyoxylic acidSummary: Both an aldehyde and a carboxylic acid
- B7869 4-Aminobenzoic acidSummary: An intermediate in the synthesis of folate0
- B7862 2-DeoxycytidineSummary: A cytidine analog
- A8703 IsosafroleTarget: Lactate Dehydrogenases (LDH)Summary: A stiripentol analog, a potent LDH inhibitor.
- A8704 StiripentolTarget: Lactate Dehydrogenases (LDH)Summary: An LDH inhibitor
- B4750 (-)-p-Bromotetramisole OxalateSummary: ALP inhibitor, potent and non-specific