Proteasome
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
- A8172 Dihydroeponemycin1 CitationSummary: Proteasome inhibitor,antitumor reagent,eponemycin ddrivative
- C4090 HMB-Val-Ser-Leu-VESummary: inhibitor of the trypsin-like activity of the 20S proteasome
- B6026 VR23Target: ProteasomeSummary: proteasome inhibitor
- B4755 PI-1840Summary: Chymotrypsin-like (CT-L) inhibitor
- A4443 Gliotoxin1 CitationTarget: 20S proteasomal chymotrypsin|Geranylgeranyltransferase I|FarnesyltransferaseSummary: 20S proteasome inhibitor
- A8163 AM 1142 CitationTarget: ProteasomeSummary: 20S proteasome inhibitor
- A1934 Oprozomib (ONX-0912)5 CitationSummary: Proteasome inhibitor
- A1933 Carfilzomib (PR-171)10 CitationTarget: ProteasomeSummary: Proteasome inhibitor, epoxomicin analog
- A1900 PSISummary: Proteasome inhibitor
- A2614 Bortezomib (PS-341)24 CitationTarget: ProteasomeSummary: Proteasome Inhibitor