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IκB/IKK

IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.

A4602 TPCA-1
2 Citation

Summary: IKK-2 inhibitor,potent and selective

insoluble in H2O; ≥13.95 mg/mL
B3033 Bay 11-7085
1 Citation

Summary: NK-κB activation inhibitor

≥12.45 mg/mL
B1585 SC-514

Summary: ATP-competitive IKK-2 inhibitor, orally active

insoluble in EtOH; insoluble in H2O; ≥50.4 mg/mL
B1586 IKK-16 (IKK Inhibitor VII)
1 Citation

Summary: Selective IκB kinase inhibitor

≥23.05 mg/mL
B5756 ML 120B dihydrochloride

Summary: IKK2-selective inhibitor

≥44 mg/mL
B4880 WS6

Summary: inducer of β cell proliferation
B4825 IKKε-IN-1

Summary: potent IKKε inhibitor

Soluble in DMSO
B4986 LY2409881

Summary: potent and selective IKK2 inhibitor

≥59.4 mg/mL
B6089 PS-1145

Summary: IKK inhibitor

≥32.3 mg/mL
C4569 IKK-16 (hydrochloride)

Summary: IκB kinases (IKKs) inhibitor

≤10 mg/mL