Elastase
Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.
- C4325 BAY-678Summary: HNE inhibitor
- C3609 (Z-Ala-Ala-Ala-Ala)2Rh110Summary: fluorogenic elastase substrate
- C3252 Neutrophil Elastase InhibitorSummary: neutrophil elastase inhibitor
- B6189 Sivelestat (ONO-5046)Summary: neutrophil elastase inhibitor
- B4676 GW311616 hydrochlorideSummary: HNE inhibitor
- B4675 GW311616Summary: inhibitor of human neutrophil elastase(HNE)
- B1037 AlvelestatTarget: NESummary: NE inhibitor
- A4431 SSR 69071Summary: HLE inhibitor
- A4430 Sivelestat sodium saltTarget: ElastasesSummary: Leukocyte elastase inhibitor
- A4432 ARP 1001 CitationTarget: MMPSummary: Selective MMP-2 inhibitor