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Elastase

Elastase is a serine protease that catalyzes not only the hydrolysis of peptide bonds of proteins but also the hydrolysis of amides and esters. Although it has similar functions as trypsin and chymotrypsin, elastase preferentially targets the protein elastin catalyzing cleavage at its neutral sites. Two major types of elastase have been identified, including pancreatic elastase and neutrophil elastase (PMN). While he pancreatic elastase is produced initially as an inactive protein requiring the activation by trypsin in the duodenum; PMN is found in relatively high levels in the azurophilic granules of circulating leukocytes and neutrophils. Both types of elastase exhibit similar activities but differ in substrate specificity and inhibitor profile.

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  1. BAY-678
    Catalog No. :
    C4325
    HNE inhibitor
  2. (Z-Ala-Ala-Ala-Ala)2Rh110
    Catalog No. :
    C3609
    fluorogenic elastase substrate
  3. Neutrophil Elastase Inhibitor
    Catalog No. :
    C3252
    neutrophil elastase inhibitor
  4. Sivelestat (ONO-5046)
    Catalog No. :
    B6189
    neutrophil elastase inhibitor
  5. GW311616 hydrochloride
    Catalog No. :
    B4676
    HNE inhibitor
    GW311616 hydrochloride is a potent, selective, intracellular, orally bioavailable and long duration inhibitor of human neutrophil elastase (HNE) with an IC50 value of 22nM .
  6. GW311616
    Catalog No. :
    B4675
    inhibitor of human neutrophil elastase(HNE)
  7. Alvelestat
    Catalog No. :
    B1037
    NE inhibitor
    Alvelestat is an orally bioavailable inhibitor of neutrophil elastase (NE) with IC50 value of pIC50 value of 7.9 .
  8. SSR 69071
    Catalog No. :
    A4431
    HLE inhibitor

    High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM?for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.

  9. Sivelestat sodium salt
    Catalog No. :
    A4430
    Leukocyte elastase inhibitor
    Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.
  10. ARP 100
    Catalog No. :
    A4432
    Selective MMP-2 inhibitor
    ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM [1].

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