MAPK Signaling
Activated MAPKs transduce the phosphorylation and activation of MAPK-activated protein kinases (MAPKAPKs), e.g. RSK, MSK, or MNK family, and MK2/3/5. There are three main MAPK families, signal-regulated kinase 1 and 2 (Erk1/2 or p44/42), the c-Jun N-terminal kinases 1-3 (JNK1-3)/ stress activated protein kinases (SAPK1A, 1B, 1C), the p38 isoforms (p38α, β, γ, and δ). ERK signaling is involved in cell division, migration and survival. p38 MAPK and JNK/SAPK pathways are activated by cellular stress. The p38 MAPK pathway regulates cell motility, transcription, and chromatin remodeling. JNK/SAPK signaling affects apoptosis and inflammation. Dysregulation of MAPK pathway results in tumorgenesis and other pathological conditions.
- C5850 SD 169Summary: selective ATP competitive inhibitor of the MAP kinases p38α and p38β
- B5727 PD 334581Summary: MEK1 inhibitor
- A9907 MEK Inhibitor SetSummary: For phosphorylation and dephosphorylation applications
- B7784 AL 8697Target: p38Summary: p38α inhibitor,potent and selective
- B7791 6-Bnz-cAMP sodium saltSummary: cAMP analog,PKA activator
- A9501 OTS514Summary: TOPK inhibitor,highly potent
- A9502 OTS964 hydrochlorideSummary: TOPK inhibitor,potent and selective
- B4886 DTP3 TFASummary: inhibitor of GADD45β/MKK7 complex
- B4937 SB 706504Summary: p38 MAPK inhibitor
- B5817 GDC-09942 CitationSummary: ERK1/2 inhibitor