MAPK Signaling
Activated MAPKs transduce the phosphorylation and activation of MAPK-activated protein kinases (MAPKAPKs), e.g. RSK, MSK, or MNK family, and MK2/3/5. There are three main MAPK families, signal-regulated kinase 1 and 2 (Erk1/2 or p44/42), the c-Jun N-terminal kinases 1-3 (JNK1-3)/ stress activated protein kinases (SAPK1A, 1B, 1C), the p38 isoforms (p38α, β, γ, and δ). ERK signaling is involved in cell division, migration and survival. p38 MAPK and JNK/SAPK pathways are activated by cellular stress. The p38 MAPK pathway regulates cell motility, transcription, and chromatin remodeling. JNK/SAPK signaling affects apoptosis and inflammation. Dysregulation of MAPK pathway results in tumorgenesis and other pathological conditions.
- Summary: selective ATP competitive inhibitor of the MAP kinases p38α and p38β
- Summary: lipophilic activator of the cyclic-AMP- and cyclic-GMP-dependent protein kinases, PKA and PKG
- Summary: orally active inhibitor of the MAP kinases p38α and p38β
- Target: MK2Summary: highly selective, non-ATP competitive MK2 inhibitor
- Summary: p38 MAPK inhibitor
- Summary: a negative control in studies of p38 inhibition
- Summary: A signal-specific JNK/p38 pathway and TAK 1 inhibitor
- Summary: potent inhibitor of PKA and PKG
- Summary: substrate for cAMP-dependent protein kinase (PKA)
- Summary: MEK1/2 inhibitor