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TGF-βR1(ALK5)

TGF-βR1 (transforming growth factor beta receptors) are a serine/threonine protein kinase that involved in the regulation of cell cycle arrest, cell proliferation and differentiation, production of extracellular matrix, wound healing, tumorgenesis and immunosuppression etc.

Items 1-10 of 14

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  1. ALK5 Inhibitor II (hydrochloride)
    Catalog No. :
    C3656
    ALK5 inhibitor
  2. ML347
    Catalog No. :
    B3688
    BMP receptor inhibitor,potent and selective
    ML347 is a potent and selective inhibitor of bone morphogenetic protein (BMP) receptor with IC50 value of 32nM against ALK2 .
  3. LDN-212854
    Catalog No. :
    B3687
    BMP receptor inhibitor,potent and selective
    LDN-212854 is a selective inhibitor of bone morphogenetic protein (BMP) signaling with IC50 value of 1.2nM .
  4. DMH-1
    Catalog No. :
    B3686
    Selective BMP ALK2 receptor
    DMH1 is a small molecule inhibitor of bone morphogenetic protein (BMP) signaling with IC50 value of 107.9nM against ALK2 .
  5. K02288
    Catalog No. :
    B2286
    ALK inhibitor
    K02288 is a highly selective inhibitor of ALK2 with IC50 value of 1.1nM .
  6. LY2109761
    Catalog No. :
    A8464
    TβRI/II kinase inhibitor
    LY2109761 is a small-molecule inhibitor selectively targeting both TGF-β receptor type I and II ((TβRI/II)) with Ki of 38 nM and 300 nM, respectively . It gave IC50 value of 69 nM in TβRI enzymatic assay . Crystal structure showed the binding of LY2109761 to the ATP binding site of the TGF-β R1 kinase domain . Weak inhibitory activities were reported for other kinases, including Lck, Sapk2α, MKK6, Fyn, and JNK3 (18–89% inhibition at 20 µM) .
  7. LY2157299
    Catalog No. :
    A8348
    TGF-βR1 inhibitor,potent and selective

    LY2157299 is a potent small-molecule antagonist that specifically inhibits Transforming Growth Factor-β receptor I (TβRI).

  8. GW788388
    Catalog No. :
    A8301
    ALK5 inhibitor,potent and selective
    GW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)].
  9. SB525334
    Catalog No. :
    A5602
    (TGF-beta1) receptor inhibitor
    SB525334 is a potent inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, activin receptor-like kinase (ALK5). It specifically inhibits ALK5 with IC50 value of 14.3nM, which shows 4-fold higher potency against ALK4 .
  10. SB 431542
    Catalog No. :
    A8249
    ALK inhibitor

    SB431542 is a selective ATP-competitive inhibitor of ALK5 (activin receptor-like kinase 5) with an IC50 value of 94 nM .

Items 1-10 of 14

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