TGF-βR1 (transforming growth factor beta receptors) are a serine/threonine protein kinase that involved in the regulation of cell cycle arrest, cell proliferation and differentiation, production of extracellular matrix, wound healing, tumorgenesis and immunosuppression etc.
- ALK5 Inhibitor II (hydrochloride)Catalog No. :C3656ALK5 inhibitor
- ML347Catalog No. :B3688BMP receptor inhibitor,potent and selectiveML347 is a potent and selective inhibitor of bone morphogenetic protein (BMP) receptor with IC50 value of 32nM against ALK2 .
- LDN-212854Catalog No. :B3687BMP receptor inhibitor,potent and selectiveLDN-212854 is a selective inhibitor of bone morphogenetic protein (BMP) signaling with IC50 value of 1.2nM .
- DMH-1Catalog No. :B3686Selective BMP ALK2 receptorDMH1 is a small molecule inhibitor of bone morphogenetic protein (BMP) signaling with IC50 value of 107.9nM against ALK2 .
- K02288Catalog No. :B2286ALK inhibitorK02288 is a highly selective inhibitor of ALK2 with IC50 value of 1.1nM .
- LY2109761Catalog No. :A8464TβRI/II kinase inhibitorLY2109761 is a small-molecule inhibitor selectively targeting both TGF-β receptor type I and II ((TβRI/II)) with Ki of 38 nM and 300 nM, respectively . It gave IC50 value of 69 nM in TβRI enzymatic assay . Crystal structure showed the binding of LY2109761 to the ATP binding site of the TGF-β R1 kinase domain . Weak inhibitory activities were reported for other kinases, including Lck, Sapk2α, MKK6, Fyn, and JNK3 (18–89% inhibition at 20 µM) .
- LY2157299Catalog No. :A8348TGF-βR1 inhibitor,potent and selective
LY2157299 is a potent small-molecule antagonist that specifically inhibits Transforming Growth Factor-β receptor I (TβRI).
- GW788388Catalog No. :A8301ALK5 inhibitor,potent and selectiveGW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)].
- SB525334Catalog No. :A5602(TGF-beta1) receptor inhibitorSB525334 is a potent inhibitor of transforming growth factor-beta1 (TGF-beta1) receptor, activin receptor-like kinase (ALK5). It specifically inhibits ALK5 with IC50 value of 14.3nM, which shows 4-fold higher potency against ALK4 .
- SB 431542Catalog No. :A8249ALK inhibitor
SB431542 is a selective ATP-competitive inhibitor of ALK5 (activin receptor-like kinase 5) with an IC50 value of 94 nM .