Cytosporone B
Catalog No.
B5961
agonist for nuclear orphan receptor Nur77
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Cytosporone B (CAS 321661-62-5), also referred to as Csn-B or Dothiorelone G, is a naturally derived small molecule that functions as a selective agonist of the nuclear orphan receptor NR4A1 (Nur77). By directly binding and activating NR4A1, Cytosporone B modulates the transcriptional activity of this receptor, altering the expression of downstream target genes. It exhibits potent agonist activity toward NR4A1, with a reported EC50 value of approximately 0.278 nM. Cytosporone B serves as a valuable research tool to investigate NR4A1-related signaling pathways, biological functions, and pathophysiological mechanisms.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 322.40 |
| Cas No. | 321661-62-5 |
| Formula | C18H26O5 |
| Solubility | ≥32.2 mg/mL in DMSO; insoluble in H2O; ≥23.55 mg/mL in EtOH |
| Chemical Name | ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC(O)=CC(CC(OCC)=O)=C1C(CCCCCCC)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
