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Cell Counting Kit-8 (CCK-8)

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Cell Counting Kit-8 (CCK-8)

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Cell Biology
Cell Proliferation & Toxicity
Cell Counting Kit-8 (CCK-8)

Cell Counting Kit-8 (CCK-8)

Catalog No.

K1018

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Used in cell proliferation assay and cytotoxicity assay

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Grouped product items
Size	Price	Stock
1x1ml (100 tests)	$20.00	In stock
1x5ml (500 tests)	$60.00	In stock
2x5ml (1000 tests)	$100.00	In stock
6x5ml (3000 tests)	$240.00	In stock
20x5ml (10000 tests)	$720.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

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2. Zhechuan Zhang, Yuanfeng Zhang, et al. "P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway." Med Oncol. 2023 Jan 2;40(2):70. PMID: 36588128
3. Chuchu Lin, Chenyi Huang, et al. "Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy." Acta Pharm Sin B. 2022 Dec;12(12):4472-4485. PMID: 36561996
4. J. Li, Q. Tian, et al. "A novel liposome-loaded injectable hydrogel for enhanced treatment of choroidal neovascularization by sub-tenon's injection." Materials Today Nano. Volume 20, December 2022, 100264.
5. Cheng Wei, Xiaoyang Zhang, et al. "LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway." Cell Death Dis. 2022 Nov 9;13(11):942. PMID: 36351895
6. Zheng Liu, Xing Luo, et al. "Enzyme-Enhanced Codelivery of Doxorubicin and Bcl-2 Inhibitor by Electrospun Nanofibers for Synergistic Inhibition of Prostate Cancer Recurrence." Pharmaceuticals (Basel). 2022 Oct 10;15(10):1244. PMID: 36297356
7. Qiong Wang, Junxiu Chen, et al. "MiR-29c-3p and MiR-223-3p regulate the proliferation and drug resistance of oral squamous cell carcinoma by targeting ANGPTL4." Front Oral Maxillofac Med 2022. Vol 4 (December 30, 2022).
8. Dejuan Sun, Yueying Yang, et al. "Identification of ADP-ribosylation factor 6 as the cellular target of withangulatin A against TNBC cells by ferroptosis." Research Square. October 14th, 2022.
9. Haiyan Wang, Hanqing Lin, et al. "miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress." Research Square. September 28th, 2022.
10. Qianying Jia, Qinggong Jia, et al. "A promoting nitric oxide-releasing coating containing copper ion on ZE21B alloy for potential vascular stent application." Journal of Magnesium and Alloys. 28 September 2022.
11. Qin Tang, Yue-ming Chen, et al. "Increased Expression of NXPH4 Correlates with Immune Cell Infiltration and Unfavorable Prognosis in Hepatocellular Carcinoma." J Oncol. 2022 Oct 6;2022:5005747. PMID: 36245978
12. Yuan Li, Qingya Dang, et al. "Restoration of Mitochondrial Function Is Essential in the Endothelium-Dependent Vasodilation Induced by Acacetin in Hypertensive Rats." Int J Mol Sci. 2022 Sep 26;23(19):11350. PMID: 36232649
13. Yufei Long, Tuotuo Chong, et al. "FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer." J Exp Clin Cancer Res. 2022 Oct 13;41(1):301. PMID: 36229838
14. Chen Chen, Heng Zhang, et al. "Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway." Evid Based Complement Alternat Med. 2022 Sep 28;2022:5219277. PMID: 36212944
15. Xiaolong Tang, Yahang Liang, et al. "Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer." Cell Death Dis. 2022 Oct 4;13(10):848. PMID: 36195596
16. Jun-Dan Wang, Jue-Qiong Xu, et al. "Mutant C/EBPα p30 alleviates immunosuppression of CD8+ T cells by inhibiting autophagy-associated secretion of IL-1β in AML." Cell Prolif. 2022 Dec;55(12):e13331. PMID: 36124714
17. Wei Zhu, Xiaofen Zhang, et al. "Profiles of Acetylation Regulation Genes Contribute to Malignant Progression and Have a Clinical Prognostic Impact on Liver Cancer." Dis Markers. 2022 Sep 10;2022:1724301. PMID: 36124029
18. Ruo-Wen Xiao, Fang Wang, et al. "Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication." EBioMedicine. 2022 Oct;84:104267. PMID: 36116213
19. LIJUN LI, ZHIHAO WEN, et al. "LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma." Int J Oncol. 2022 Oct;61(4):129. PMID: 36102310
20. Lijuan Bian, Xi Rui, et al. "Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer." Cell Biosci. 2022 Sep 10;12(1):153. PMID: 36088396
21. Zijuan Wu, Danling Gu, et al. "CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis." Exp Hematol Oncol. 2022 Sep 5;11(1):51. PMID: 36064433
22. Anne Behre, Joshua W Tashman, et al. "3D Bioprinted Patient‐Specific Extracellular Matrix Scaffolds for Soft Tissue Defects." Adv Healthc Mater. 2022 Sep 5;e2200866. PMID: 36063047
23. Peng Ye, Zhanhu Mi, et al. "miR-3960 from Mesenchymal Stem Cell-Derived Extracellular Vesicles Inactivates SDC1/Wnt/ β-Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by Targeting PHLDA2." Stem Cells Int. 2022 Aug 25;2022:9455152.. PMID: 36061148
24. Jierong Chen, Lixue Cao, et al. "HDAC8 Promotes Liver Metastasis of Colorectal Cancer via Inhibition of IRF1 and Upregulation of SUCNR1." Oxid Med Cell Longev. 2022 Aug 16;2022:2815187. PMID: 36035205
25. Caiji Lin, Zheng Zeng, et al. "Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota." Phytomedicine. 2022 Nov;106:154401. PMID: 36029647
26. Qing Zhang, Yue Zhou, et al. "Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer." Biomed Pharmacother. 2022 Sep;153:113426. PMID: 36017794
27. Xin Ming, Huan Chen, et al. "Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication." Viruses. 2022 Aug 15;14(8):1782. PMID: 36016404
28. Wang Liao, Xinyi Cao, et al. "Pea Protein-Derived Peptides Inhibit Hepatic Glucose Production via the Gluconeogenic Signaling in the AML-12 Cells." Int J Environ Res Public Health. 2022 Aug 18;19(16):10254. PMID: 36011893
29. Xin Shen, Weiwen Zhu, et al. "Macrophage miR-149-5p induction is a key driver and therapeutic target for BRONJ." JCI Insight. 2022 Aug 22;7(16):e159865. PMID: 35993364
30. Qiang Wang, Chen Chen, et al. "APAF1‐Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly." Adv Sci (Weinh). 2022 Oct;9(28):e2201889. PMID: 35975461
31. Junyu Zheng, Cong Li, et al. "A 5`-tRNA Derived Fragment NamedtiRNA-Val-CAC-001 Works as a Suppressor in Gastric Cancer." Cancer Manag Res. 2022 Aug 4;14:2323-2337. PMID: 35958946
32. Jing Han, Gang-Hua Feng, et al. "Classifying mild cognitive impairment and Alzheimer's disease by constructing a 14-gene diagnostic model." Am J Transl Res. 2022 Jul 15;14(7):4477-4492. PMID: 35958496
33. Xiaoli Liu, Huikun Zhang, et al. "Knockdown of Girdin Induced Apoptosis of Glioblastoma Cells via the Mitochondrion Signaling Pathway." Neuroscience. 2022 Sep 15;500:95-105. PMID: 35952993
34. Li‑Ming Xu, Ya‑Jing Yuan, et al. "LINC00665 knockdown confers sensitivity in irradiated non-small cell lung cancer cells through the miR-582-5p/UCHL3/AhR axis." J Transl Med. 2022 Aug 2;20(1):350. PMID: 35918714
35. Chunhua Tian, Jing Su, et al. "lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN." Comput Math Methods Med. 2022 Jul 20;2022:9304392. PMID: 35912140
36. Xiaoyu Feng, Wenfeng Hu, et al. "Taurine Ameliorates Iron Overload-Induced Hepatocyte Injury via the Bcl-2/VDAC1-Mediated Mitochondrial Apoptosis Pathway." Oxid Med Cell Longev. 2022 Jul 16;2022:4135752. PMID: 35879990
37. Qi Dong, Dan Zu, et al. "Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects." Biomater Res. 2022 Jul 25;26(1):36. PMID: 35879746
38. Thomas Später, Marisa Assunção, et al. "Engineering microparticles based on solidified stem cell secretome with an augmented pro-angiogenic factor portfolio for therapeutic angiogenesis." Bioact Mater. 2022 Apr 2;17:526-541. PMID: 35846945
39. Can Cui, Yuting Pan, et al. "Eltrombopag binds SDC4 directly and enhances MAPK signaling and macropinocytosis in cancer cells." Am J Cancer Res. 2022 Jun 15;12(6):2697-2710. PMID: 35812066
40. Zijuan Wu, Luqiao Wang, et al. "Exploring the significance of PAK1 through chromosome conformation signatures in ibrutinib-resistant chronic lymphocytic leukaemia." Mol Oncol. 2022 Aug;16(16):2920-2935. PMID: 35811334
41. Yang Liu, Libo He, et al. "Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway." iScience. 2022 Jun 6;25(7):104533. PMID: 35784791
42. Chengtao Sun, Mengzhen Li, et al. "IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma." Cell Death Dis. 2022 Jun 27;13(6):572. PMID: 35760783
43. Di Zhao, Chao Shi, et al. "Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing." Pharmaceuticals (Basel). 2022 Jun 15;15(6):750. PMID: 35745669
44. Weibo Zhong, Kaihui Wu, et al. "Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-κB-IL6-STAT3 axis." Microbiome. 2022 Jun 16;10(1):94. PMID: 35710492
45. Ruili Guan, Changhao Yang, et al. "Dehydroepiandrosterone alleviates hypoxia-induced learning and memory dysfunction by maintaining synaptic homeostasis." CNS Neurosci Ther. 2022 Sep;28(9):1339-1350. PMID: 35703574
46. Zhicheng Cao, Hongmei Wang, et al. "Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration." Bioact Mater. 2022 May 31;20:221-242. PMID: 35702612
47. Yanlin Wu, Xuan Li, et al. "Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration." Bioact Mater. 2022 May 23;20:111-125. PMID: 35663335
48. Haiyan Xing, Qiang Liu, et al. "Cadmium mediates pyroptosis of human dermal lymphatic endothelial cells in a NLRP3 inflammasome-dependent manner." J Toxicol Sci. 2022;47(6):237-247. PMID: 35650140
49. Jianjun Qi, Zihua Zeng, et al. "Aptamer-Gemcitabine Conjugates with Enzymatically Cleavable Linker for Targeted Delivery and Intracellular Drug Release in Cancer Cells." Pharmaceuticals (Basel). 2022 Apr 30;15(5):558. PMID: 35631384
50. Hongjin Chen, Yuchen Jiang, et al. "Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation." Molecules. 2022 May 11;27(10):3076. PMID: 35630552
51. Jieping Zhang, Shaomin Zou, et al. "3,3'-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer." Metabolites. 2022 Apr 30;12(5):410. PMID: 35629914
52. Wei Wang, Xiaolong Liang, et al. "NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway." J Nanobiotechnology. 2022 May 23;20(1):241. PMID: 35606794
53. Qing Liu, Qiyao Li, et al. "circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease." Cell Death Dis. 2022 May 19;13(5):477. PMID: 35589691
54. Yu Cai, Cuixi Wu, et al. "Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1." Bioact Mater. 2022 May 2;19:444-457. PMID: 35574050
55. He Ding, Zhiqiang Li, et al. "FTO Alleviates CdCl2-Induced Apoptosis and Oxidative Stress via the AKT/Nrf2 Pathway in Bovine Granulosa Cells." Int J Mol Sci. 2022 Apr 29;23(9):4948. PMID: 35563339
56. Yanxue Wang, Shuo Luan, et al. "The Combined Use of Platelet-Rich Plasma Clot Releasate and Allogeneic Human Umbilical Cord Mesenchymal Stem Cells Rescue Glucocorticoid-Induced Osteonecrosis of the Femoral Head." Stem Cells Int. 2022 May 2;2022:7432665. PMID: 35547633
57. Jianqiang Zhu, Leyi Liu, et al. "Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium." Environ Pollut. 2022 Aug 1;306:119421. PMID: 35533959
58. Xi Wang, Mengmeng Zhang, et al. "Exosomal AFAP1-AS1 binds to microRNA-15a-5p to promote the proliferation, migration, and invasion of ectopic endometrial stromal cells in endometriosis." Reprod Biol Endocrinol. 2022 May 5;20(1):77. PMID: 35513844
59. Haojie Chen, Jia Luo, et al. "Non-drug efflux function of ABCC5 promotes enzalutamide resistance in castration-resistant prostate cancer via upregulation of P65/AR-V7." Cell Death Discov. 2022 May 3;8(1):241. PMID: 35504877
60. Wei Yu, Weidong Liu, et al. "High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis." Oxid Med Cell Longev. 2022 Apr 18;2022:9304383. PMID: 35480874
61. Tianli Wu, Hui Tang, et al. "METTL3-m6 A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway." Cell Prolif. 2022 May;55(5):e13234. PMID: 35470497
62. Dandan Feng, Jiang Li, et al. "DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model." J Biochem Mol Toxicol. 2022 Aug;36(8):e23077. PMID: 35467791
63. Xinyu Zhou, Nanqu Huang, et al. "Icaritin attenuates 6-OHDA-induced MN9D cell damage by inhibiting oxidative stress." PeerJ. 2022 Apr 12;10:e13256. PMID: 35433120
64. Chang Kong, Xuqing Ni, et al. "ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking." Cell Death Discov. 2022 Apr 9;8(1):187. PMID: 35397620
65. Xiaohua Zhu, YingYing Xie, et al. "NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer." BMC Cancer. 2022 Mar 29;22(1):339. PMID: 35351053
66. Zaiyong Zhang, Jianhao Li, et al. "Regulatory Mechanism of circEIF4G2 Targeting miR-26a in Acute Myocardial Infarction." J Healthc Eng. 2022 Mar 16;2022:5308372. PMID: 35340248
67. Bopei Li, Yeyang Chen, et al. "Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis." Cell Death Dis. 2022 Mar 8;13(3):217. PMID: 35260554
68. Haixia Wu, Youliang Yan, et al. "miR-4324 inhibits ovarian cancer progression by targeting FEN1." J Ovarian Res. 2022 Mar 4;15(1):32. PMID: 35246224
69. Ying Liu, Guangwei Ma, et al. "Global chromosome rearrangement induced by CRISPR-Cas9 reshapes the genome and transcriptome of human cells." Nucleic Acids Res. 2022 Apr 8;50(6):3456-3474. PMID: 35244719
70. Nan Zhang, Yan Shen, et al. "The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability." Exp Mol Med. 2022 Feb;54(2):194-205. PMID: 35217832
71. Xiaowu Ma, Hongkai Zhuang, et al. "SLC39A1 Overexpression is Associated with Immune Infiltration in Hepatocellular Carcinoma and Promotes Its Malignant Progression." J Hepatocell Carcinoma. 2022 Feb 15;9:83-98. PMID: 35211427
72. Zongyi Liu, Huanyu Xiang, et al. "Revealing potential anti-fibrotic mechanism of Ganxianfang formula based on RNA sequence." Chin Med. 2022 Feb 18;17(1):23. PMID: 35180857
73. Jingjing Wang, Xu Zhu, et al. "Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t (4; 14) translocation." J Clin Invest. 2022 Feb 15;132(4):e149526. PMID: 35166240
74. Daoyuan Hu, Yunlong Ge, et al. "Upregulated IGFBP3 with Aging Is Involved in Modulating Apoptosis, Oxidative Stress, and Fibrosis: A Target of Age-Related Erectile Dysfunction." Oxid Med Cell Longev. 2022 Feb 3;2022:6831779. PMID: 35154570
75. Bin Wang, Jing Zhang, et al. "Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway." Autophagy. 2022 Oct;18(10):2350-2367. PMID: 35130104
76. Zhaoyi Pan, Yujie Feng, et al. "MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules." Virulence. 2022 Dec;13(1):355-369. PMID: 35129074
77. Jianjun Ma, Xiaoxue Shi, et al. "MicroRNA-181a-2-3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson's disease by inhibiting EGR1 and NOX4." Cell Death Discov. 2022 Jan 24;8(1):33. PMID: 35075150
78. MAHA ABDULLA, THAMER BIN TRAIKI, et al. "Targeting MUCL1 protein inhibits cell proliferation and EMT by deregulating β‑catenin and increases irinotecan sensitivity in colorectal cancer." Int J Oncol. 2022 Mar;60(3):22. PMID: 35059735
79. Jingjing Zhang, Yun Li, et al. "Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis." J Exp Clin Cancer Res. 2022 Jan 15;41(1):24. PMID: 35033172
80. Qingwen Li, Jiao Zhang, et al. "MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9." Eur J Histochem. 2022 Jan 12;66(1):3275. PMID: 35016493
81. Lin Liu, Yongwu Yang, et al. "Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated NLRP3 Deubiquitination." Cells. 2021 Dec 6;10(12):3425. PMID: 34943932
82. Na Qiu, Xiaoye Yang, et al. "A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases." J Nanobiotechnology. 2021 Dec 19;19(1):428. PMID: 34923976
83. Bo Sun, Xianyu Zheng, et al. "LncRNA LINC01303 Promotes the Progression of Oral Squamous Cell Carcinomas via the miR-429/ZEB1/EMT Axis." J Oncol. 2021 Dec 6;2021:7974012. PMID: 34912458
84. Yiming Xu, Dandan Lv, et al. "METTL3 Promotes Lung Adenocarcinoma Tumorigenesis and Inhibits Ferroptosis by Stabilizing SLC7A11 m6A Modification." Research Square. rs-1085921/v1.
85. Jian Wang, Qinjiang Bian, et al. "Identification and in vitro validation of prognostic lncRNA signature in head and neck squamous cell carcinoma." Bioengineered. 2021 Dec;12(2):10049-10062. PMID: 34872450
86. Xueshan Zhao, Xiaodong Jin, et al. "Silencing of the lncRNA H19 enhances sensitivity to X-ray and carbon-ions through the miR-130a-3p /WNK3 signaling axis in NSCLC cells." Cancer Cell Int. 2021 Dec 4;21(1):644. PMID: 34863180
87. YAQI ZHOU, XUESHUANG MEI, et al. "Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β-catenin pathways." Oncol Lett. 2022 Jan;23(1):20. PMID: 34858524
88. Yi Zhou, Jing Li, et al. "Rhophilin rho GTPase binding protein 1-antisense RNA 1 (RHPN1-AS1) promotes ovarian carcinogenesis by sponging microRNA-485-5p and releasing DNA topoisomerase II alpha ( TOP2A)." Bioengineered. 2021 Dec;12(2):12003-12022. PMID: 34787052
89. Jiehua He, Ziqiang Chu, et al. "Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer." J Hematol Oncol. 2021 Nov 15;14(1):194. PMID: 34781990
90. Tian Tian, Fu Hong, et al. "HSD17B6 downregulation predicts poor prognosis and drives tumor progression via activating Akt signaling pathway in lung adenocarcinoma." Cell Death Discov. 2021 Nov 8;7(1):341. PMID: 34750355
91. Hongtao Zhen, Peng Du, et al. "LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA." BMC Cancer. 2021 Oct 26;21(1):1145. PMID: 34702201
92. Xu Zhao, Jizhao Wang, et al. "DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin resistance of lung squamous cell carcinoma through modulating miR-181a-5p/miR-382-5p/CELF1 axis." Sci Rep. 2021 Oct 25;11(1):21014. PMID: 34697393
93. Yong Xie, Yangping Chen, et al. "Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway." Stem Cells Int. 2021 Oct 15;2021:2229477. PMID: 34691190
94. Yan Liang, Chao Qian, et al. "JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12." Cell Death Discov. 2021 Oct 22;7(1):306. PMID: 34686673
95. Lei Gao, Xiaolong Tang, et al. "Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway." Cell Death Discov. 2021 Oct 11;7(1):281. PMID: 34635639
96. Wenwen Liu, Yang Zhou, et al. "Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis." Clin Transl Med. 2021 Sep;11(9):e517. PMID: 34586745
97. D Cai, S Chen, et al. "Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds." Mater Today Bio. 2021 Aug 19;12:100127. PMID: 34585135
98. Weian Zhao, Lu Yang, et al. "Cardiac-Specific Gene TNNI3 as a Potential Oncogene for Kidney Cancer and Its Involvement in Wnt Signaling Pathway." Research Square. rs-754351/v1.
99. Li-Ming Liu, Qiang Tang, et al. "Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer." Life (Basel). 2021 Aug 5;11(8):789. PMID: 34440533
100. Yongjian Zhou, Nanqu Huang, et al. "Icaritin protects SH-SY5Y cells transfected with TDP-43 by alleviating mitochondrial damage and oxidative stress." PeerJ. 2021 Aug 10;9:e11978. PMID: 34434670
101. Yingnan Liu, Yao Li, et al. "Development and in vivo evaluation of MGF100-1R deletion mutant in an African swine fever virus Chinese strain." Vet Microbiol. 2021 Oct;261:109208. PMID: 34419775
102. Yandong Bao, Ying Qiao, et al. "miRNA-27a Transcription Activated by c-Fos Regulates Myocardial Ischemia-Reperfusion Injury by Targeting ATAD3a." Oxid Med Cell Longev. 2021 Aug 8;2021:2514947. PMID: 34413925
103. Shaoqian Cui, Lei Zhang. "microRNA-129-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates intervertebral disc degeneration via blockade of LRG1-mediated p38 MAPK activation." J Tissue Eng. 2021 Jul 29;12:20417314211021679. PMID: 34377430
104. Chaozhong Peng, Xiao Li, et al. "Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer." Sci Rep. 2021 Aug 10;11(1):16243. PMID: 34376787
105. Jing Liu, Jiahuan Wang, et al. "MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression." Aging (Albany NY). 2021 Aug 9;13(15):19805-19821. PMID: 34370714
106. Lulin Tan, Zhaojun Chen, et al. "MicroRNA Profiling Reveals an Abundant sscmiRNA-148a-3p that Promotes Proliferation and Differentiation during Intramuscular Adipogenesis in Chinese Guizhou Congjiang Pigs Breeds by targeting PPARGC1A." Research Square. rs-818015/v1.
107. Zhenyu Zhao, Gen Li, et al. "Capturing Magnesium IonsviaMicrofluidic Hydrogel Microspheres for Promoting Cancellous Bone Regeneration." ACS Nano. 2021 Aug 24;15(8):13041-13054. PMID: 34342981
108. Chunyan Wang, Tianli Zhang, et al. "ER-α36 Promotes the Malignant Progression of Cervical Cancer Mediated by Estrogen via HMGA2." Front Oncol. 2021 Jul 14;11:712849. PMID: 34336701
109. Rongxue Shao, Liang Zhang, et al. "Autophagy activation promotes the effect of iPSCs-derived NSCs on bladder function restoration after spinal cord injury." Tissue Cell. 2021 Oct;72:101596. PMID: 34333229
110. Qingqing Hu, Xiaochu Hu, et al. "Upregulation of SGOL2 Predicts Poor Prognosis and Facilitates Hepatocellular Carcinoma Progression via Dysregulating the Cell Cycle by Directly Activating MAD2." Research Square. rs-560609/v1.
111. Bingquan Jiana, Jiaqi Pang, et al. "Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss." Toxicol Lett. 2021 Oct 10;350:249-260. PMID: 34302894
112. Jian‑Ping Zhang, Wei‑Jing Zhang, et al. "Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis." Mol Med. 2021 Jul 15;27(1):77. PMID: 34266379
113. Qingsong Jiang, Xiaoya He, et al. "d-Alanine metabolic pathway, a potential target for antibacterial drug designing in Enterococcus faecalis." Microb Pathog. 2021 Sep;158:105078. PMID: 34245823
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124. Liang Y, Wang J. "Sorafenib-Induced Exosome Secretion Promotes Che-motherapy Resistance in Hepatoma Cell Line." Japanese J Gstro Hepato. 2021; V6(12): 1-7.
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128. Xiaolie He, Yanjing Zhu, et al. "MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells." Adv Sci (Weinh). 2021 Feb 25;8(9):2003535. PMID: 33977050
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132. Geng Li, Linghui Zhang. "miR-335-5p aggravates type 2 diabetes by inhibiting SLC2A4 expression." Biochem Biophys Res Commun. 2021 Jun 18;558:71-78. PMID: 33901926
133. Ning Li, Xiaoping Li, et al. "Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling." Int J Biol Sci. 2021 Apr 3;17(5):1382-1394. PMID: 33867853
134. Keting Bao, Yongyun Li, et al. "Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway." Cell Death Dis. 2021 Apr 7;12(4):380. PMID: 33828201
135. Xiangli Zhuang, Bo Wu, et al. "Effect of Xingbi Gel Nasal Drops on Fyn-STAT5 Pathway in Nasal Mucosa Fibroblasts of Guinea Pigs with Allergic Rhinitis." Evid Based Complement Alternat Med. 2021 Mar 20;2021:6686815. PMID: 33824677
136. Yuzhen Liao, Zhi Zhou, et al. "Cell-friendly photo-functionalized TiO 2 nano-micro-honeycombs for selectively preventing bacteria and platelet adhesion." Mater Sci Eng C Mater Biol Appl. 2021 Apr;123:111996. PMID: 33812616
137. Mei-sa Wang, Qiu-shuang Han, et al. "PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway." Acta Pharmacol Sin. 2022 Jan;43(1):167-176. PMID: 33772142
138. Yuefei Zhang, Yiqing Li, et al. "Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin." J Extracell Vesicles. 2021 Mar;10(5):e12078. PMID: 33732417
139. Yilei Zhang, Robert V Swanda, et al. "mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation." Nat Commun. 2021 Mar 11;12(1):1589. PMID: 33707434
140. Jiancong Lu, Junhong Lin, et al. "MiR-328-3p inhibits lung adenocarcinoma-genesis by downregulation PYCR1." Biochem Biophys Res Commun. 2021 Apr 23;550:99-106. PMID: 33706104
141. Xiaohong Pu, Qing Ye, et al. "Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas." Cell Death Dis. 2021 Mar 11;12(3):256. PMID: 33692336
142. Wujing Dai, Han Qu, et al. "Far Upstream Binding Protein 1 (FUBP1) participates in translational regulation of Nrf2 protein under oxidative stress." Redox Biol. 2021 May;41:101906. PMID: 33676361
143. Yue Wang, Hui-Li Wang, et al. "S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs." Toxicol Appl Pharmacol. 2021 Apr 1;416:115469. PMID: 33640343
144. Yu Wang , Wei Gao. "Effects of TNF-α on autophagy of rheumatoid arthritis fibroblast-like synoviocytes and regulation of the NF-κB signaling pathway." Immunobiology. 2021 Mar;226(2):152059. PMID: 33561598
145. Ge Tian, Yang Yu, et al. "Empagliflozin alleviates ethanol-induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway." Clin Exp Pharmacol Physiol. 2021 Jun;48(6):837-845. PMID: 33527532
146. Zemin Li, Han Yin, et al. "The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis." Ecotoxicol Environ Saf. 2021 Mar 15;211:111945. PMID: 33516137
147. Rongrong Yan, Shuangfen Jin, et al. "Dexmedetomidine inhibits cell malignancy in osteosarcoma cells via miR-520a-3p-YOD1 interactome." Biochem Biophys Res Commun. 2021 Mar 5;543:56-64. PMID: 33515913
148. Zeyu Zheng, Xuyang Zhang, et al. "Site-1 protease controls osteoclastogenesis by mediating LC3 transcription." Cell Death Differ. 2021 Jun;28(6):2001-2018. PMID: 33469231
149. Jizhao Wang, Yuchen Sun, et al. "Oxidative stress activates NORAD expression by H3K27ac and promotes oxaliplatin resistance in gastric cancer by enhancing autophagy flux via targeting the miR-433-3p." Cell Death Dis. 2021 Jan 18;12(1):90. PMID: 33462197
150. Bo Wang, Ying Huang, et al. "Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions." Lasers Med Sci. 2022 Feb;37(1):299-307. PMID: 33439377
151. Guoqiang Fan, Yanfei Li, et al. "DHA/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly." Cell Death Dis. 2021 Jan 12;12(1):73. PMID: 33436541
152. Rui-Qi Wang, Xiao-Ran Long, et al. "Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer." J Exp Clin Cancer Res. 2021 Jan 6;40(1):9. PMID: 33407724
153. Peng Zhao, Jianhua Cheng, et al. "LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis." Cancer Cell Int. 2021 Jan 6;21(1):14. PMID: 33407504
154. John Culver Taylor, Xinsheng Gao, et al. "A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors." PLoS Pathog. 2021 Jan 6;17(1):e1009182. PMID: 33406160
155. Guangyu Ji, Wenjuan Zhou, et al. "Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster." Mol Med Rep. 2021 Mar;23(3):187. PMID: 33398374
156. Yun-Feng Zheng, Dan-Yang Li, et al. "Comprehensive Comparison of Two Color Varieties of Perillae Folium Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q/TOF-MS)-Based Metabolic Profile and in Vivo/ in Vitro Anti-Oxidative Activity." J Agric Food Chem. 2020 Dec 9;68(49):14684-14697. PMID: 33237758
157. Pei-Ting Lin, Xiao-Dong Xue, et al. "Necrostatin-1, RIP1/RIP3 inhibitor, relieves transforming growth factor β-induced wound-healing process in formation of hypertrophic scars." J Cosmet Dermatol. 2020 Nov 25. PMID: 33237588
158. Kai Guo, Lei Song, et al. "AEBP1 Promotes Glioblastoma Progression and Activates the Classical NF-κB Pathway." Behav Neurol. 2020 Nov 6;2020:8890452. PMID: 33224311
159. Zhenyao Chen, Qinnan Chen, et al. "Long non-coding RNA CASC9 promotes gefitinib resistance in NSCLC by epigenetic repression of DUSP1." Cell Death Dis. 2020 Oct 14;11(10):858. PMID: 33056982
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100 tests	1 mL x 1
500 tests	5 mL x 1
1000 tests	5 mL x 2
3000 tests	5 mL x 6
10000 tests	5 mL x 20
Store at 4°C away from light, stable for 1 year. For long-term storage, store it at -20°C.

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Our product Cell Counting Kit-8 (CCK-8) provide a more convenient and sensitive method for the research of cell number determination and cell proliferationtotoxicity assay than previous ways. The kit utilizes a highly water-soluble tetrazolium salt, WST-8, which produces a water-soluble formazan dye upon reduction in the presence of an electron mediator. The amount of the formazan generated by dehydrogenases is directly in proportion to the numbers of living cells. The detection sensitivity by CCK-8 is higher than other tetrazolium salts such as MTT, XTT, MTS or WST-1.

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More Sensitive than MTT, MTS, or WST-1

No Toxicity to Cell

Simpler Steps, No organic solvents required

Stable One Bottle Solution, ready-to-use

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Store at 4°C.

Cell Counting Kit-8 (CCK-8)

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Tyramide Signal Amplification (TSA)

Phos Binding Reagent Acrylamide

Cell Counting Kit-8 (CCK-8)

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