Toggle Nav

Cathepsin

Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

Items 1-10 of 13

Page
per page
  1. 2-cyano-Pyrimidine
    Catalog No. :
    C5038
    cathepsin K inhibitor
  2. Cathepsin Inhibitor 1
    Catalog No. :
    B2084
    Cathepsin inhibitor
    Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
  3. Odanacatib (MK-0822)
    Catalog No. :
    A2487
    Cathepsin K,potent and selective
    Odanacatib (MK-0822) is a potent, orally active and selective inhibitor of Cathepsin K with IC50 value of 0.20 nM ,
  4. CA-074 Me
    Catalog No. :
    A8239
    Cathepsin B inhibitor

    CA-074 Me is a membrane-permeable and selective inhibitor of cathepsin B with IC50 value of 36.3 nM [1, 2].

  5. SID 26681509
    Catalog No. :
    A4424
    Human cathepsin L inhibitor,potent and reversible
    Potent and reversible human cathepsin L inhibitor (IC50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.
  6. MDL 28170
    Catalog No. :
    A4412
    Calpain and cathepsin B inhibitor, selective

    MDL 28170 is a selective inhibitor, which inhibites calpain with Ki values of 10nM and cathepsin B with Ki values of 25 nM while does not inhibit trypsin-like serine proteases.

  7. L 006235
    Catalog No. :
    A4422
    Cathepsin K inhibitor
    Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.
  8. Cathepsin S inhibitor
    Catalog No. :
    A3284
    Blocks MHCII antigen presentation
    A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
  9. E-64-c
    Catalog No. :
    A8162
    Inhibitor of cysteine proteinases

    E-64-c, which is also known as Ep-475, is an analog of E-64 and inhibitor of cysteine proteinases.

  10. CA 074
    Catalog No. :
    A1926
    Cathepsin B inhibitor
    Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

Items 1-10 of 13

Page
per page