Toggle Nav

PI3K/Akt/mTOR Signaling

The PI3K/Akt/mTOR signaling pathway is a key regulator in growth, survival, cell cycle proliferation, protein synthesis and glucose metabolism. Growth factors, hormones, and cytokines can activate this pathway by binding their cognate receptor tyrosine kinase (RTK), cytokine receptor, or GPCR, resulting in the activation of lipid kinase PI3K which produces PIP3 at the plasma membrane.

The binding of PIP3 translocates Akt to cell membranes, enables Akt activation through phosphorylation at Thr308 mediated by phosphoinositide dependent kinase 1 (PDK1). In addition, Akt is phosphorylated at Ser473 by the mTOR-rictor complex, mTORC2. PTEN is a negative regulator of Akt signaling that reverses the function of PI3K by removing 3’-phosphate groups. Akt activity is also negatively regulated by the phosphatases PP2A and PHLPP. Akt propagates its signal to affect DNA transcription, cell cycle and apoptosis. Akt can activate mTOR directly by phosphorylation or indirectly, by phosphorylation and inactivation of mTOR inhibitor TSC2 and PRAS40. Together these mechanisms stimulate cell growth and G1 cell cycle progression through signaling via p70 S6 Kinase and inhibition of 4E-BP1. Defects in PI3K/AKT/mTOR signaling are implicated in cancer, diabetes and cardiovascular disease etc.

Items 1-10 of 194

Page
per page
  1. 740 Y-P
    Catalog No. :
    B5246
    PI 3-kinase activator,cell permeable

    740 Y-P is an activator of PI3K with concentration of 20 μM [1].

  2. PI-3065
    Catalog No. :
    B4660
    P110δkinase inhibitor
    PI-3065 is a small molecule and selective inhibitor of p110δkinase with an Ki value of 1.5nM and IC50 value of 5nM .
  3. WZ4003
    Catalog No. :
    B1374
    NUAK1/2 inhibitor, potent and selective
    WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.
  4. Niclosamide Ethanolamine salt
    Catalog No. :
    B8383
    An anthelmintic originally, mitochondrial uncoupler in parasitic worms and other animals, also used in prevention and treatment of obesity and type 2 diabetes
  5. Akt Inhibitor IV
    Catalog No. :
    C5867
  6. Rapalink-1
    Catalog No. :
    A8764
    third-generation mTOR inhibitor
  7. GDC-0084
    Catalog No. :
    B7826
    PI3K and mTOR inhibitor, brain-permeable
    GDC-0084 is a potent and brain penetrant inhibitor of PI3K and mTOR with Ki values of 2 nM and 70 nM for PI3Kα and mTOR, respectively [1].
  8. 3-Guanidinopropionic Acid
    Catalog No. :
    C5645
    AMPK stimulator
  9. NG,NG-dimethyl-L-Arginine (hydrochloride)
    Catalog No. :
    C5216
    endogenous nitric oxide synthase inhibitor
  10. KP372-1
    Catalog No. :
    C5053
    specific Akt inhibitor

Items 1-10 of 194

Page
per page