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Stem Cell

Stem cells are a class of undifferentiated cells that are able to differentiate into specialized tissue cell types. There are two types of stem cells: embryonic stem cells (ESC) and adult stem cells (ASC). The ESC is originated from the inner cell of blastocysts, and the ASC is located in specific tissues, such as bone marrow, adipose tissue and blood.

In ESC, BMP/TGF-β signaling pathway plays a key role in maintaining pluripotency and self-renewal. It signals through Smad proteins, and the FGF signaling pathway, which activates the MAPK and Akt pathways. The Wnt signaling pathway also promotes pluripotency. OCT-4, SOX2, and NANOG are three main transcription factors that are expressed and activated by these pathways. Induced pluripotent stem cells (iPSC) are pluripotent cells that can be generated from differentiated cells with forced expression of specific reprogramming factors. Both ESC and iPSC can be induced to develop into distinct cell types that associated with three primary germ layers: ectoderm, mesoderm and endoderm. Signaling pathways that control the development of these cell lineages, including BMP/TGF-β, Notch, Wnt/β-catenin, Hedgehog and Hippo pathways, which regulate cell division, growth and differentiation. Defects in stem cell signaling are related to developmental disorders and cancer.

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  1. XMU-MP-1
    Catalog No. :
    A8735
    MST1/2 inhibitor, potent and selective

    XMU-MP-1 is a reversible, potent and selective inhibitor of MST1/2 with IC50 values of 71.1 ± 12.9 nM and 38.1 ± 6.9 nM, respectively [1].

  2. QS 11
    Catalog No. :
    B7364
    ARFGAP1 inhibitor,Wnt/beta-catenin pathway modulator
    New Product
  3. Stem Cell Set I
    Catalog No. :
    A9905
    For inhibiting HDAC/ GSK-3α/β /histone methyltransferase /ALK5
  4. HLY78
    Catalog No. :
    C5433
    positive modulator of the Wnt/β-catenin pathway
  5. CUR 61414
    Catalog No. :
    C5138
    potent inhibitor of hedgehog-induced cellular activity
  6. Oxy-16
    Catalog No. :
    C5136
    antagonist of hedgehog activity
  7. ML-243
    Catalog No. :
    C4813
    inhibitor of cancer stem cells
  8. RSC-133
    Catalog No. :
    C4664
    promotes the reprogramming of human somatic cells to pluripotent stem cells
  9. ALLO-1
    Catalog No. :
    C4582
    SMO antagonist
  10. BRD7116
    Catalog No. :
    C4227
    inhibitor of leukemia stem cell activity

Items 1-10 of 126

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