Bcl-2 Family
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
- A8783 VU661013Summary: Novel, potent, selective MCL-1 inhibitor
- B4881 UMI-771 CitationTarget: Mcl-1Summary: Mcl-1 inhibitor, novel
- B4902 (+)-ApogossypolTarget: Bcl-2Summary: inhibitor of Bcl-2 family proteins
- B5846 Radotinib(IY-5511)Target: PDGFR|Bcr-AblSummary: Bcr-Abl tyrosine kinase inhibitor
- B5978 BDA-366Target: Bcl-2Summary: Selective antagonist of BCL2 BH4 domain
- B6011 A-12104772 CitationTarget: Mcl-1Summary: MCL-1 inhibitor
- A8737 S6384511 CitationTarget: MCL1Summary: MCL1 inhibitor
- B6094 BH3I-1Summary: Bcl-2 or Bcl-XL inhibitor
- B1080 Marinopyrrole ATarget: Mcl-1Summary: Selective Mcl-1 inhibitor
- A8168 HA14-1Target: Bcl-2Summary: Bcl-2 inhibitor,potent and cell-permeable