(+)-Apogossypol
Catalog No.
B4902
inhibitor of Bcl-2 family proteins
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(+)-Apogossypol (CAS 66389-74-0) is a pan-BCL-2 family protein antagonist exhibiting activity against anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1. By binding directly to these targets, it inhibits their anti-apoptotic functions, thereby promoting apoptosis. Reported EC50 values for binding to Mcl-1, Bcl-2, and Bcl-xL are 2.6 μM, 2.8 μM, and 3.69 μM, respectively. This compound is utilized in research focused on apoptosis signaling pathways and cancer drug screening involving the BCL-2 protein family.
References:
[1] Yedida G, Milani M, et al. "Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis." Cell Death Dis. 2019 Jul 8;10(7):521. PMID:31285422
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 462.53 |
| Cas No. | 66389-74-0 |
| Formula | C28H30O6 |
| Solubility | insoluble in H2O; ≥16.2 mg/mL in DMSO with gentle warming; ≥2.54 mg/mL in EtOH with ultrasonic |
| Chemical Name | 5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexaol |
| SDF | Download SDF |
| Canonical SMILES | CC(C)c(c(cc1C)c(cc2O)c(O)c1-c(c(C)cc(c(C(C)C)c1O)c3cc1O)c3O)c2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
