AT-101 (acetic acid)
Catalog No.
B8366
An inhibitor of anti-apoptotic proteins in the Bcl-2 family, inducing apoptosis.
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AT-101 (acetic acid) is the levorotatory isomeric form of the natural product Gossypol and can act on Bcl-2 family proteins. Studies have shown that AT-101 can bind to anti-apoptotic proteins such as Bcl-2, Mcl-1, and Bcl-xL, with Ki values of 260±30 nM, 170±10 nM, and 480±40 nM, respectively, thereby inhibiting their function. AT-101 is commonly used for research on apoptosis mechanisms, as well as for exploring the roles related to targeting anti-apoptotic pathways in anti-tumor drug development.
| Physical Appearance | A solid |
| Storage | -20°C |
| M.Wt | 578.61 |
| Cas No. | 866541-93-7 |
| Formula | C32H34O10 |
| Solubility | insoluble in H2O; ≥20.6 mg/mL in DMSO; ≥25.75 mg/mL in EtOH |
| Chemical Name | acetic acid compound with (R)-1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-8,8'-dicarbaldehyde (1:1) |
| Canonical SMILES | CC(O)=O.O=CC(C1=C(O)[C@@]([C@@]2=C(C=C(C(C(C)C)=C(O)C(O)=C3C=O)C3=C2O)C)=C(C)C=C1C(C(C)C)=C4O)=C4O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |