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EWS-FLI1 is a transcription factor specific to the Ewing’s sarcoma. EWS-FL1I coupling to RHA (RNA helicase A) is essential for its oncogenic function.

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 Paper Citing APExBIO Products  Ongoing Clinical Trials  Solubility in DMSO  Solubility in Water  Solubility in Ethanol  Solubility in Dimethyl Formamide
  1. RK-33
    B7810 RK-33
    Target: DDX3
    Summary: DDX3 (a RNA helicase) inhibitor
      ≥21.4 mg/mL
  2. YK-4-279
    A3946 YK-4-279
    Target: RHA
    Summary: RNA Helicase A (RHA) inhibitor
      ≥16.35 mg/mL
      ≥24.25 mg/mL
      <2.44 mg/mL

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