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PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

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  1. 4-amino-1,8-Naphthalimide
    Catalog No. :
    C4310
    PARP inhibitor
  2. Benzamide
    Catalog No. :
    B6152
    poly (ADP-ribose) synthetase inhibitor
  3. Picolinamide
    Catalog No. :
    B6150
    poly (ADP-ribose) synthetase inhibitor
  4. BGP-15
    Catalog No. :
    B6086
    PARP inhibitor
  5. MK-4827 tosylate
    Catalog No. :
    B1164
    PARP1/PARP2 inhibitor
    MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
  6. MK-4827 hydrochloride
    Catalog No. :
    B1163
    PARP1/PARP2 inhibitor
    MK-4827(Niraparib) Hcl is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.
  7. ME0328
    Catalog No. :
    A8808
    PARP inhibitor,potent and selective
    ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
  8. Tankyrase Inhibitors (TNKS) 49
    Catalog No. :
    A8601
    Tankyrase inhibitor
    Tankyrase Inhibitors (TNKS) 49 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1nM .
  9. Tankyrase Inhibitors (TNKS) 22
    Catalog No. :
    A8600
    Tankyrase inhibitor
    Tankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1nM .
  10. XAV-939
    Catalog No. :
    A1877
    Tankyrase 1/2 inhibitor

    XAV-939 is a small-molecule inhibitor of tankyrase 1/2 with IC50 values of 4 and 11 nM, respectively .

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