Neuroscience
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A3316 Clemizole hydrochlorideTarget: Histamine H1 Receptors|TRPC channelSummary: H1 histamine receptor antagonist
- B5292 BTS 54-505 hydrochlorideSummary: Potent SNRI,sibutramine metabolite
- B5347 SC 58125Summary: COX-2 inhibitor
- B5355 YM 230888Summary: Selective mGlu1 antagonist
- B5406 NAD 299 hydrochlorideSummary: Selective, high affinity 5-HT1A receptor antagonist
- B5422 CP 99994 dihydrochlorideSummary: High affinity NK1 antagonist
- B5473 GSK 264220ASummary: endothelial lipase and lipoprotein lipase inhibitor
- B5510 SR 140333Summary: NK1 receptor antagonist
- B5513 JNJ 5207852 dihydrochlorideSummary: histamine H3 receptor neutral antagonist
- B5532 NPS 2390Target: Glutamate (Metabotropic) Group I ReceptorsSummary: group I mGlu antagonist