Neuroscience
Neurotransmitter receptors function via various G-protein coupled and G-protein independent mechanisms that activate downstream intracellular signaling pathways such as cAMP/PKA, PI3K/AKT, phospholipase A2, and phospholipase C pathways. For instance, dopamine receptors act through adenylate cyclase to activate PKA and other signaling molecules, thereby mediate gene expression through the actions of CREB and other transcription factors. Other neurotransmitters such as NMDAR or AMPAR are associated with ion channels that control flux of Ca2+ and Na+, thus propagating the action potential across the post-synaptic neuron.
Dysfunctions in GABAergic/glutamatergic/serotonergic/dopaminergic pathways result in a broad range of neurological disorders such as chronic pain, neurodegenerative diseases, and insomnia, as well as mental disorders including schizophrenia, bipolar disorder, depression, and addiction.
- A3316 Clemizole hydrochlorideTarget: Histamine H1 Receptors|TRPC channelSummary: H1 histamine receptor antagonist
- A1123 Amyloid Beta-Peptide (12-28) (human)Summary: sequence H2N-VHHQKLVFFAEDVGSNK-OH
- A1124 Amyloid Beta-Peptide (1-40) (human)1 CitationSummary: Amyloid precursor protein
- C5736 Valeroyl SalicylateSummary: selective, irreversible inhibitor of cyclooxygenase-1 (COX-1)
- C5755 (S)-NaproxenSummary: non-selective COX inhibitor
- A1129 Parathyroid hormone (1-34) (human)Summary: Increases blood calcium level
- C4812 N-tert-butyl-α-PhenylnitroneSummary: COX-2 inhibitor
- A1132 β-PompilidotoxinTarget: sodium channelsSummary: Slows Na+ channel inactivation
- A1002 Beta-Amyloid (1-11)Summary: Amyloidogenic peptide
- A1003 Amyloid β-Protein (1-15)Summary: Principal component of amyloid