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HER2

HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.

Items 1-10 of 14

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  1. Lapatinib Ditosylate
    A3967 Lapatinib Ditosylate
    Target: EGFR|ErbB-2
    Summary: EGFR/HER2 inhibitor,potent and selective
      ≥24.3 mg/mL
  2. Lapatinib
    A8218 Lapatinib
     2 Citation
    Target: ErbB
    Summary: EGFR/HER2 inhibitor,potent,selective and reversible
      ≥29.05 mg/mL
  3. Afatinib (BIBW2992)
    A8247 Afatinib (BIBW2992)
     1 Citation
    Target: EGFR
    Summary: Irreversible EGFR/HER2 inhibitor
      ≥24.3 mg/mL
  4. CP-724714
    A2412 CP-724714
    Target: VEGFR|PDGFR|Bcr-Abl|Src|EGFR|c-MET|Insulin Receptors|IRG-1R
    Summary: HER2 inhibitor,potent and selective
      ≥23.5 mg/mL
  5. Pelitinib (EKB-569)
    A1835 Pelitinib (EKB-569)
    Summary: EGFR inhibitor,potent and irreversible
      insoluble in EtOH; insoluble in H2O; ≥11.7 mg/mL
  6. AC480 (BMS-599626)
    A2822 AC480 (BMS-599626)
    Target: EGFR
    Summary: HER1/2 inhibitor,selective and efficacious
      ≥28.35 mg/mL
  7. Neratinib (HKI-272)
    A8322 Neratinib (HKI-272)
     1 Citation
    Target: EGFR
    Summary: HER2/EGFR inhibitor,potent and irreversible
      insoluble in H2O; ≥13.93 mg/mL
  8. TAK-285
    A8528 TAK-285
    Target: EGFR|HER2
    Summary: HER2/EGFR(HER1) inhibitor
      ≥27.4 mg/mL
  9. Mubritinib (TAK 165)
    B1543 Mubritinib (TAK 165)
    Target: ErbB
    Summary: Potent inhibitor of HER2/ErbB2
      insoluble in H2O; ≥76.9 mg/mL
  10. Tyrphostin AG 879
    B1544 Tyrphostin AG 879
    Summary: HER2 inhibitor

Items 1-10 of 14

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