Anti-CD137 & Her2 Antibody (Cinrebafusp alfa)
Catalog No.
F1433
Anti-CD137 & Her2 Antibody (Cinrebafusp alfa)
Featured Products
Cinrebafusp alfa (PRS 343) is a high-affinity CD137/HER2 bispecific anti-calcitonin drug. Cinrebafusp alfa binds recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa promotes T cell co-stimulation through tumor-localized HER2-dependent 4-1BB aggregation and activation, further enhancing T cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential to be used in the study of HER2+ solid tumors.
Quality Control & DataSheet
- View current batch:
-
Purity > 95% by SDS-PAGE and SEC-HPLC analyses.
- MSDS (Material Safety Data Sheet)
- Datasheet
187.86 kDa
Dry ice
2218515-90-1
-80°C
2 years
Liquid
See label
For reconstitution, we recommend adding sterile, distilled water to achieve a final antibody concentration. Gently shake it to solubilize the protein completely. Do not vortex.
CHO
PRS-343
100 mM Pro 20 mM Arg pH 5.0. No preservative!
Q07011 & P04626
Human
Unconjugated
Monoclonal
Protein A
IgG4
ELISA, FACS, Kinetics, Functional assay, Animal Model
Human 4-1BB NF-κB Jurkat cells were stained with Anti-CD137 & Her2 Reference Antibody (Cinrebafusp alfa) and negative control protein respectively, washed and then followed by PE and analyzed with FACS
CD137 & Her2
Please avoid freeze-thaw cycles.