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EZH2

EZH2 (enhancer of zeste homolog 2) is a polycomb group protein and histone methyltrasferase that associated with transcriptional repression. It catalyzes trimethylation of H3K27me3 (histone H3 lysine 27) as a catalytic subunit of PRC2 (polycomb repressive complex 2).

Relate Categories
Category
  • CK1 5items
  • Cancer stem cell 3items
  • ESC 1item
  • EZH2 8items
  • GSK-3 21items
  • HSC 5items
  • Hedgehog 21items
  • Hippo Signaling 1item
  • MST1/2 1item
  • Notch 3items
  • Smoothened 11items
  • Wnt/β-catenin 40items
  • iPSC 8items
Specificity
  1. Selective 7 items
Target
  1. EZH2 5 items
  2. Hydrolase 1 item
  3. EZH1 1 item
Reported Experiments
  1. Animal Experiments 5 items
  2. Cell Experiments 5 items
Related Disease
  1. Acute Myeloid Leukemia 2 items
  2. Bladder Cancer 1 item
  3. Breast Cancer 2 items
  4. Cancer 6 items
  5. Lung Cancer 1 item
  6. Lymphoma 1 item
  7. Ovarian Cancer 1 item
  8. Prostate Cancer 2 items