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EZH2

EZH2 (enhancer of zeste homolog 2) is a polycomb group protein and histone methyltrasferase that associated with transcriptional repression. It catalyzes trimethylation of H3K27me3 (histone H3 lysine 27) as a catalytic subunit of PRC2 (polycomb repressive complex 2).

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  1. GSK503
    Catalog No. :
    B5833
    EZH2 inhibitor

    GSK503 is a potent inhibitor of EZH2.

  2. CPI-169
    Catalog No. :
    B4678
    EZH2 inhibitor
    CPI-169 is a novel, small molecule and potent inhibitor of enhancer of zeste homolog 2 (EZH2) with an IC50 value of <1nM for polycomb repressive complex 2 (PRC2) .
  3. EI1
    Catalog No. :
    B1021
    EZH2 inhibitor
    EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively.
  4. GSK343
    Catalog No. :
    A3449
    EZH2 inhibitor,potent,selective and cell permeable

    GSK343 is a selective and SAM-competitive inhibitor of the histone lysine methyltransferase EZH2 with IC50 value of 4 nM [1].

  5. GSK126
    Catalog No. :
    A3446
    EZH2 inhibitor

    GSK126 is an inhibitor of EZH2 with Ki Value of 93 pM.

  6. 3-Deazaneplanocin,DZNep
    Catalog No. :
    A1905
    S-adenosylhomocysteine and EZH2 inhibitor

    3-Deazaneplanocin is a highly potent inhibitor of S-adenosylhomocysteine hydrolase with Ki value of 0.05 nM .

  7. EPZ005687
    Catalog No. :
    A4171
    EZH2 inhibitor,potent and selective

    EPZ005687 is a potent inhibitor of EZH2, an enzymatic subunit of polycomb repressive complex 2 (PRC2) catalyzing the methylation of histone H3 lysine 27 (H3K27), that inhibits EZH2 with a value of inhibition constant Ki of 24 nM, which is 500-fold and 50-fold greater in selectivity than 15 other protein methyltransferases and closely related EZH1 respectively.

  8. 3-Deazaneplanocin A (DZNep) hydrochloride
    Catalog No. :
    A8182
    SAHH and EZH2 inhibitor

    3-Deazaneplanocin A (DZNep) hydrochloride is a selective inhibitor of ENZ2 inhibitor with IC50 value of 0.08-0.24 μM.

8 Items

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