Angiogenesis
During tumor angiogenesis, cancer cells stimulate formation of new blood vessel for delivering oxygen and nutrients to a tumor. As the tumor grows, cells at the center of the mass become starved of oxygen, causing hypoxia. It stabilizes the expression of a transcription factor, HIF-1α (hypoxia inducible factor-1), which binds HIF-1β to upregulate the expression of several angiogenesis-promoting genes. Moreover, growth factor signaling also stimulates HIF-1 activity in order to maintain oxygen homeostasis for growing cells.
- B1408 CNX-774Summary: BTK inhibitor, orally active, irreversible and selective
- A4507 KC7F2Summary: HIF-1α inhibitor
- A4509 PX 12Target: TrxSummary: Trx-1 inhibitor
- A4506 DMOGTarget: Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs)Summary: Competitive HIF-PH inhibitor, cell-permeable
- A8229 ML161Target: Protease-Activated ReceptorsSummary: PAR1 inhibitor
- A8233 DMXAA (Vadimezan)2 CitationTarget: DT-diaphorasesSummary: Tumnor vascular disrupting agent, apoptosis inducer
- A8636 RN486Summary: Btk inhibitor,potent and selective
- A8660 Cilengitide1 CitationTarget: IntegrinsSummary: Integrin inhibitor for αvβ3 and αvβ5
- A8661 MNSSummary: Inhibitor of Src/Syk tyrosine kinases
- A8662 A 205804Summary: E-selectin/ICAM-1 expression inhibitor