Angiogenesis
During tumor angiogenesis, cancer cells stimulate formation of new blood vessel for delivering oxygen and nutrients to a tumor. As the tumor grows, cells at the center of the mass become starved of oxygen, causing hypoxia. It stabilizes the expression of a transcription factor, HIF-1α (hypoxia inducible factor-1), which binds HIF-1β to upregulate the expression of several angiogenesis-promoting genes. Moreover, growth factor signaling also stimulates HIF-1 activity in order to maintain oxygen homeostasis for growing cells.
- Summary: BTK inhibitor, orally active, irreversible and selective
- Summary: cell permeable, competitive inhibitor of HIF-PH
- Summary: Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor
- Summary: HIF-prolyl hydroxylase-2 (PHD2) inhibitor
- Summary: prolyl hydroxylases (PHD) activator
- Target: BTKSummary: irreversible BTK inhibitor
- Summary: HIF-prolyl hydroxylase inhibitor
- Summary: αvβ3 antagonist
- Summary: Highly potent and selective oral Btk inhibitor
- Summary: BTK-specific tyrosine kinase inhibitor