A 205804
Catalog No.
A8662
E-selectin/ICAM-1 expression inhibitor
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A 205804 (CAS 251992-66-2) is a selective inhibitor targeting the expression of adhesion molecules E-selectin and ICAM-1, exhibiting IC50 values of 20 nM and 25 nM, respectively. E-selectin and ICAM-1 mediate endothelial-leukocyte interactions essential in inflammatory responses. In human endothelial cell assays (e.g. HUVECs), A 205804 reduces ICAM-1 and E-selectin expression, thus attenuating leukocyte-endothelial adhesion and migration. Mechanistically, A 205804 translocates to the nucleus, binding non-covalently to large (>650 kDa) molecular targets. A 205804 serves as a research tool for studying inflammatory processes and adhesion-associated diseases.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 300.39 |
| Cas No. | 251992-66-2 |
| Formula | C15H12N2OS2 |
| Solubility | ≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | Cc(cc1)ccc1Sc1cncc2c1cc(C(N)=O)[s]2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 values of 20 nM and 25 nM, respectively. | |||||
| Targets | E-selectin | ICAM-1 | ||||
| IC50 | 20 nM | 25 nM | ||||
Quality Control & MSDS
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Chemical structure
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