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A 205804

Catalog No.
A8662
E-selectin/ICAM-1 expression inhibitor
Grouped product items
SizePriceStock Qty
50mg
$329.00
In stock
10mg
$79.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

A 205804 (CAS 251992-66-2) is a selective inhibitor targeting the expression of adhesion molecules E-selectin and ICAM-1, exhibiting IC50 values of 20 nM and 25 nM, respectively. E-selectin and ICAM-1 mediate endothelial-leukocyte interactions essential in inflammatory responses. In human endothelial cell assays (e.g. HUVECs), A 205804 reduces ICAM-1 and E-selectin expression, thus attenuating leukocyte-endothelial adhesion and migration. Mechanistically, A 205804 translocates to the nucleus, binding non-covalently to large (>650 kDa) molecular targets. A 205804 serves as a research tool for studying inflammatory processes and adhesion-associated diseases.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt300.39
Cas No.251992-66-2
FormulaC15H12N2OS2
Solubility≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Chemical Name4-(4-methylphenyl)sulfanylthieno[2,3-c]pyridine-2-carboxamide
SDFDownload SDF
Canonical SMILESCC1=CC=C(C=C1)SC2=C3C=C(SC3=CN=C2)C(=O)N
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 values of 20 nM and 25 nM, respectively.
Targets E-selectin ICAM-1        
IC50 20 nM 25 nM        

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