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Membrane Transporter/Ion Channel

Membrane Transporters mediate the movement of ions and molecules via binding and moving the substance across the membrane. There are two main actions of transporter: facilitated diffusion (passive transport) and active transport. Membrane transporters which bind the hydrolysis of ATP to the transport of target molecules are referred to as ATPases. For instance, Na+,K+-ATPases or Na+,K+-pumps are responsible for the transport of Na+ out of and K+ into cells.

Ion channels are pore-forming membrane proteins which allow the flow of ions across the membrane. The ion channels can be broadly grouped into six families including calcium channels, chloride channels, potassium channels, sodium channels, gap junction proteins and porins. Not all ion channels are gated, such as certain type of K+ and Cl– channels, transient receptor potential superfamily of cation channels, the ryanodine receptors and the IP3 receptors, but most Na+, K+, Ca2+ and some Cl– channels are all gated by voltage. Ligand-gated channels are regulated in response to ligand binding (e.g. neurotransmitters signaling). These ligand-gated neurotransmitter receptors are known as ionotropic receptors. Various neurotransmitters couple to ionotropic receptors such as glutamate, acetylcholine, glycine, GABA, and serotonin.

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  1. Spadin
    Catalog No. :
    B6071
    TREK-1 channel inhibitor
  2. DPNI-caged-GABA
    Catalog No. :
    B5356
    activates GABAA receptor

    New Product

  3. Ethacrynic Acid
    Catalog No. :
    C4125
    Na+/K+/2Cl- cotransporter NKCC2 inhibitor
  4. Clopamide
    Catalog No. :
    C3286
    sodium/chloride cotransporters inhibitor
  5. Oligomycin Complex
    Catalog No. :
    C3007
    inhibits mitochondrial membrane-bound ATP synthases
  6. Brilliant Blue G
    Catalog No. :
    C5579
    used for protein staining in SDS-PAGE, Blue Native PAGE, and the Bradford Method; selective inhibitor of the P2X purinoceptor channel P2X7
  7. Guanidinoethyl sulfonate
    Catalog No. :
    C5294
    competitive glycine receptor antagonist
  8. 6-(4-Methoxyphenyl)-3-pyridazinamine
    Catalog No. :
    C5195
    GABAA receptor antagonist
  9. GSK1016790A
    Catalog No. :
    C5065
    TRPV4 agonist
  10. Quinacrine (hydrochloride hydrate)
    Catalog No. :
    C5039
    voltage-dependent sodium channels blocker

Items 1-10 of 686

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