KEAP1-Nrf2
The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
- Summary: Nrf2 activator
- Summary: inducer of chemopreventative enzymes via Keap1-Nrf2 signaling
- Summary: Nrf2 activator
- Summary: indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
- Target: Nrf2Summary: Nrf2 activator
- Summary: nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator
- 1 CitationTarget: Histone Deacetylases (HDACs)|Nrf2|Histone Acetyltransferases (HATs)|TyrosinasesSummary: Tyrosinase inhibitor
- Target: COX|iNOSSummary: Once-a-day treatment for CKD
- 1 CitationTarget: Nrf2/ARE signal|PPARSummary: Nrf2/ARE signal activator and PPARγ agonist
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