Curcumin
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity, with an IC50 of 47 μM. It modulates multiple signaling pathways involved in tumorigenesis and inflammation, influencing transcription factors, growth factors, cytokines, receptors, and enzymes. Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day; however, oral bioavailability is limited (~1% in Phase I/II studies). Additionally, curcumin demonstrates potential for Alzheimer's research, as evidenced by reducing beta-amyloid (Aβ40, Aβ42) production via downregulating presenilin-1 and GSK-3β in SH-SY5Y neuroblastoma cells.
- 1. Aimei Li, Xue Tian, et al. "Alkaline phosphatase-responsive peptide amphiphiles promote the apoptosis of HER2-positive breast cancer cells via increased drug accumulation." Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 718, 5 August 2025, 136848.
- 2. Jiamin Qin, Guojuan Fan, et al. "Dynamic Covalent Bond-Based Nanoassembly of Curcumin to Enhance the Selective Photothermal Therapy for Tumor Treatment." Int J Nanomedicine. 2025 Mar 30:20:3861-3875 PMID: 40181832
- 3. Maryam Khosravi. "Forward and Reverse Genetic Approaches to Studying Ciliopathy in Zebrafish." University College London.2019.
- 4. Byrd SK. "Apoptosis as the focus of an authentic research experience in a cell physiology laboratory. Adv Physiol Educ." 2016 Jun;40(2):257-64. PMID: 27231261
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 368.39 |
| Cas No. | 458-37-7 |
| Formula | C21H20O6 |
| Synonyms | Indian Saffron;Turmeric yellow;Natural Yellow 3;Diferuloylmethane |
| Solubility | ≥36.8 mg/mL in DMSO; insoluble in H2O; ≥3.5 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C(CC(/C=C/C1=CC=C(O)C(OC)=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
|
Cell lines |
B16-R melanoma cells resistant to doxorubicin |
|
Reaction Conditions |
1 ~ 200 μM curcumin for 24, 36 or 48 h incubation |
|
Applications |
Curcumin was found to be cytotoxic in vitro for B16-R melanoma cells resistant to doxorubicin either cultivated as monolayers (1 ~ 100 μM) or grown in three-dimensional cultures (1 ~ 200 μM). The cytotoxic effect observed in the 2 culture types was related to the induction of programmed cell death. |
| Animal experiment:[1] | |
|
Animal models |
Female B6D2F1 mice (6 ~ 8 weeks old) challenged subcutaneously with B16-R melanoma cells |
|
Dosage form |
25 mg/kg Once daily by intraperitoneal injection |
|
Applications |
The combination treatment consisting of curcumin and soluble B16-R proteins resulted in substantial inhibition of growth of B16-R melanoma, whereas each treatment by itself showed little effect. Moreover, animals receiving the combination therapy exhibited an enhancement of their humoral anti-soluble B16-R protein immune response and a significant increase in their median survival time. Therefore, curcumin may provide a valuable tool for the development of a therapeutic combination against the melanoma. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Odot J, Albert P, Carlier A, et al. In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells. International Journal of Cancer, 2004, 111(3): 381-387. |
|
Quality Control & MSDS
- View current batch:
Chemical structure
