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TGF-β / Smad Signaling

Transforming growth factor beta (TGF-β)/Smad signaling pathway is involved in a number of cellular processes, including cell growth, differentiation, motility and adhesion etc. This signaling pathway plays a crucial part in mammalian development as well as in tumor suppression through inhibition of proliferation and induction of apoptosis in multiple cell types.

The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.

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  1. Tamoxifen
    Catalog No. :
    B5965
    TGF-β modulatory and PKC inhibitory effects
  2. EW-7197
    Catalog No. :
    B5946
    Selective inhibitor of TGF-β type I receptor kinase
  3. ITD 1
    Catalog No. :
    B5858
    The first selective TGFβ inhibitor
  4. (-)-epicatechin gallate
    Catalog No. :
    B4965
    major catechin in green tea
  5. (-)-epicatechin
    Catalog No. :
    B4964
    inducer of pancreatic β-cell regeneration
  6. 1,2-Dimyristoyl-sn-glycerol
    Catalog No. :
    C4885
  7. 1,2-Dilauroyl-sn-glycerol
    Catalog No. :
    C4882
  8. 1,2-Distearoyl-sn-glycerol
    Catalog No. :
    C4877
  9. Hexadecyl Methyl Glycerol
    Catalog No. :
    C5388
    protein kinase C activity inhibitor
  10. UCN-02
    Catalog No. :
    C4829
    protein kinase C inhibitor

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