TGF-β / Smad Signaling
Transforming growth factor beta (TGF-β)/Smad signaling pathway is involved in a number of cellular processes, including cell growth, differentiation, motility and adhesion etc. This signaling pathway plays a crucial part in mammalian development as well as in tumor suppression through inhibition of proliferation and induction of apoptosis in multiple cell types.
The TGF-β family is generally classified into two sub-families, TGF-β ligands, and bone morphogenic protein (BMP) ligands. In canonical signaling, receptor activation lead to phosphorylation of a group of transcription factors called Smads. TGF-β ligands bind to type II receptors (TGF-β II) which recruit and phosphorylate type I receptor (TGF-β I) on serine/threonine residues. The TGF-β I then recruits and phosphorylates a receptor regulated Smad (R-Smad). The R-Smad binds to the common Smad (Co-Smad) and forms a heterodimeric complex. This complex then translocates into the cell nucleus where it binds with nuclear co-factors to regulate the transcription of various target genes. Dysregulation of TGF-β/Smad signaling pathway is associated with a number of pathological conditions including fibrosis, cancer, immunodeficiency, diabetes and cardiovascular diseases etc.
Items 31-40 of 109
- B5219 [Ala113]-MBP (104-118)Summary: Non-competitive inhibitor of PKC
- B5218 [Ala107]-MBP (104-118)Summary: Non-competitive inhibitor of PKC
- B5174 PKC β pseudosubstrateSummary: Selective cell-permeable peptide inhibitor of protein kinase C
- B5172 Pseudo RACK1Summary: Activator of protein kinase C
- B7704 LY 333531 hydrochlorideSummary: PKCβ inhibitor
- B7598 Phorbol 12,13-dibutyrateSummary: Protein kinase C activator
- B7272 FR 2369241 CitationSummary: PKC-ε activator, selective
- B7056 CGP 53353Summary: PKCβII inhibitor
- B7033 Bryostatin 11 CitationSummary: PKC activator
- B6807 Calphostin CSummary: protein kinase C inhibitor