Dehydrogenase
Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.
- B5354 CGP 3466B maleateTarget: GAPDHSummary: GAPDH inhibitor
- B5508 Alda 1Target: Aldehyde DehydrogenasesSummary: ALDH2 activator
- B5643 TC HSD 21Summary: 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor
- B5799 Qc 1Summary: threonine dehydrogenase (TDH) inhibitor
- A8704 StiripentolTarget: Lactate Dehydrogenases (LDH)Summary: An LDH inhibitor
- A8703 IsosafroleTarget: Lactate Dehydrogenases (LDH)Summary: A stiripentol analog, a potent LDH inhibitor.
- B4928 CVT 10216Summary: reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2)
- B4929 GSK 2837808ATarget: Lactate Dehydrogenases (LDH)Summary: Potent, selective lactate dehydrogenase A (LDHA) inhibitor
- A8721 CBR-58841 CitationTarget: 3-phosphoglycerate dehydrogenaseSummary: selective inhibitor of PHGDH
- B6104 BVT 2733Summary: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor