Dehydrogenase
Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.
- A4333 CPI-6131 CitationTarget: Pyruvate dehydrogenases (PDH)Summary: PDH/α-KGDH inhibitor
- A4336 Mycophenolate MofetilSummary: IMPDH inhibitor
- A4339 AGI-51981 CitationSummary: IDH1 inhibitor against R132 mutant,selective and cell-permeable
- A4342 GimeracilSummary: Dihydropyrimidine dehydrogenase inhibitor
- A4348 TrilostaneSummary: 3β-HSD inhibitor
- A4351 PluriSIn #1 (NSC 14613)Target: Stearoyl-CoA 9-desaturase (SCD-1)Summary: SCD1 inhibitor
- A3146 AGI-6780Target: IDH2Summary: IDH2/R140Q mutation inhibitor
- B5354 CGP 3466B maleateTarget: GAPDHSummary: GAPDH inhibitor
- B5508 Alda 1Target: Aldehyde DehydrogenasesSummary: ALDH2 activator
- B5643 TC HSD 21Summary: 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor