Dehydrogenase
Dehydrogenases, belonging to the class of oxidoreductases which catalyze donor-acceptor reactions to transfer electron molecules from the oxidant to the reluctant, are a diverse group of enzymes that are able to transfer one or more hydrides (H-) from a substrate to an electron acceptor, such as nicotinamide adenine dinucleotide (NAD+), nicotinamide adenine dinucleotide phosphate (NADP+) or Riboflavin, through oxidation and reduction. Three commonly studied dehydrogenase enzymes include alcohol dehydrogenase (ADH) which catalyzes the reduction of acetylaldehyde to ethanol in plant cells, succinate dehydrogenase which oxidizes succinate to fumarate, and lactate dehydrogenase which catalyzes the reversible oxidation of lactate to pyruvate.
- C5478 NCT-502Summary: inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH)
- C5603 A-771726Summary: dihydroorotate dehydrogenase inhibitor
- C4845 PHGDH-inactiveSummary: inactive analog of the 3-phosphoglycerate dehydrogenase (PHGDH) inhibitors NCT-502 and NCT-503
- C4671 Inosine-5'-monophosphate (sodium salt hydrate)Summary: substrate of IMP dehydrogenase (IMPDH)
- C4497 6-AminonicotinamideSummary: 6-phosphogluconate dehydrogenase inhibitor
- C3853 NCT-503Summary: 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor
- C3535 Piericidin ASummary: mitochondrial complex I inhibitor
- C3039 STK393606Summary: competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH
- B7824 ML390Summary: human DHODH inhibitor
- B7805 AG-120Summary: mutant IDH1 inhibitor