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CYP3A/CYP450

CYP3A4 is an enzyme of cytochrome P450 superfamily found in human liver. It catalyzes the metabolism of endogenous and exogenous agents ( e.g. xenobiotics).

Items 1-10 of 17

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  1. Cobicistat (GS-9350)
    A4313 Cobicistat (GS-9350)
    Target: Cytochrome P450 (CYP450)
    Summary: Selective CYP3A inhibitor
      insoluble in H2O; ≥150.9 mg/mL
  2. Voriconazole
    A4320 Voriconazole
    Summary: CYP51 inhibitor
      ≥34.9 mg/mL
  3. Clarithromycin
    A4322 Clarithromycin
    Target: Cytochrome P450 (CYP450)
    Summary: CYP3A inhibitor, potent
      ≥31.2 mg/mL
  4. Dronedarone
    A3374 Dronedarone
    Target: Cytochrome P450 (CYP450)|sodium channel|adrenergic receptor|potassium channel|calcium channel
    Summary: CYP3A4 and 2D6 inhibitor,moderate
      ≥27.84 mg/mL
  5. 6,7-dihydroxy Bergamottin
    C4880 6,7-dihydroxy Bergamottin
    Summary: potent inhibitor of CYP3A4
      ≤10 mg/mL
  6. 4-phenyl-1,2,3-Thiadiazole
    C4691 4-phenyl-1,2,3-Thiadiazole
    Summary: selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1)
      ≤10 mg/mL
  7. DDMS
    C5228 DDMS
    Summary: CYP4A2 enzyme inhibitor
      ≤20 mg/mL
  8. PPOH
    C5234 PPOH
    Summary: inhibitor of CYP epoxidase activity on arachadonic acid
      ≤100 mg/mL
  9. 4β-hydroxy Cholesterol
    C5540 4β-hydroxy Cholesterol
    Summary: marker for CYP3A4/5 activity
      ≤20 mg/mL
  10. ABT
    B7737 ABT
    Summary: Cytochrome P450 inhibitor
      ≥12.93 mg/mL

Items 1-10 of 17

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