DNA Damage/DNA Repair
The DNA in a human cell receives tens of thousands of damages per day due to both external (exogenous) and internal (endogenous) stress. The exogenous damages are caused by chemical contamination, UV light, ionizing radiation and alkylation/methylation etc, while the endogenous damages are coming from oxidation, alkylation and hydrolysis of bases etc. Since single strand and double strand breaks of DNA will occur after the damage, unrepaired DNA damage leads to cell senescent, apoptosis and malignancies etc. To overcome this threat, cell has developed DNA damage response, to detect DNA damage and mediate its repair.
DNA repair involves multiple mechanisms such as mismatch, base excision, and nucleotide excision repair etc. A group of proteins and pathways are participated in those processes. ATM/ATR kinases and DNA-PK are crucial for the detection of the DNA damage. Chromatin remodelers regulate chromatin accessibility for the DNA repair factors to function. RPA, Rad51 and the fanconi anemia proteins act directly on repairing the DNA damage. p53 network, the RAS GTPase superfamily, and the ubiquitin system also play important part in the DNA damage response. Aberrant DNA damage response is linked to aging, cancer and immune diseases.
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- A8705 SCR76 CitationSummary: DNA ligase IV inhibitor
- C5790 9-amino CamptothecinSummary: topoisomerase I inhibitor
- C5851 MI-192Summary: inhibitor of histone deacetylases (HDACs)
- C5006 UK 1Summary: inhibitor of topoisomerase II and hepatitis C viral replication
- C4941 SCR7 pyrazineSummary: inhibitor of DNA ligase IV
- C4764 TrimidoxSummary: specific ribonucleotide reductase inhibitor
- C4732 Illudin SSummary: potent antitumor sesquiterpene
- C4558 IsoxanthopterinSummary: interferes with RNA and DNA synthesis
- C4327 CBHASummary: HDAC inhibitor
- C4451 TrioxsalenSummary: intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light