PDE
PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.
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C5183 IbudilastSummary: inhibitor of PDE4 -
C4942 Sp-Cyclic AMPS (sodium salt)Summary: cAMP derivative used to bind PDE10 GAF domain -
C4805 ML-030Summary: PDE4 inhibitor -
C4686 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfideSummary: phosphodiesterase 7 (PDE7) inhibitor -
C4796 EggmanoneSummary: selective inhibitor of PDE4 -
C3510 MBCQSummary: cGMP-specific phosphodiesterase PDE V inhibitor -
C3266 Amino TadalafilSummary: analog of tadalafil, a potent inhibitor of phosphodiesterase 5 -
B6073 Sildenafil mesylateSummary: PDE5 inhibitor -
B5642 TC-E 5005Summary: PDE10A inhibitor -
B5630 PiclamilastSummary: PDE4 inhibitor