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PDE

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

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  1. Apremilast (CC-10004)
    A4317 Apremilast (CC-10004)
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4 inhibitor
      ≥23.05 mg/mL
  2. Roflumilast
    A4319 Roflumilast
    Summary: PDE-4 inhibitor
      insoluble in H2O; ≥20.2 mg/mL
  3. Sildenafil Citrate
    A4321 Sildenafil Citrate
    Target: Phosphodiesterases (PDEs)
    Summary: Treat erectile dysfunction and PAH
      ≥25.35 mg/mL
  4. Vardenafil HCl Trihydrate
    A4323 Vardenafil HCl Trihydrate
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor, potent and selective
      ≥13.3 mg/mL
  5. PF-2545920
    A4325 PF-2545920
    Target: Phosphodiesterases (PDEs)
    Summary: PDE10A inhibitor,potent and selective
      insoluble in H2O; ≥19.35 mg/mL
  6. Tadalafil
    A4327 Tadalafil
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥16.6 mg/mL
  7. Rolipram
    A4328 Rolipram
    Target: Phosphodiesterases (PDEs)
    Summary: PDE4-inhibitor and an anti-inflammatory agent
      insoluble in H2O; ≥13 mg/mL
  8. Cilomilast
    A4329 Cilomilast
    Target: Phosphodiesterases (PDEs)
    Summary: Potent PDE4 inhibitor
      insoluble in H2O; ≥12.95 mg/mL
  9. GSK256066
    A4331 GSK256066
    Summary: PDE4-inhibitor, selective and highly potent
      insoluble in DMSO; insoluble in EtOH; insoluble in H2O
  10. Avanafil
    A4334 Avanafil
    Target: Phosphodiesterases (PDEs)
    Summary: PDE5 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥17.6 mg/mL

Items 1-10 of 54

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