Rosiglitazone
Rosiglitazone (CAS: 122320-73-4) is a synthetic thiazolidinedione (TZD) that functions as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor highly expressed in adipose tissues. Upon ligand binding, PPARγ forms heterodimers with retinoid X receptors, promoting transcriptional activation of genes regulating adipogenesis, glucose uptake, lipid metabolism, and insulin sensitivity. Through modulating fatty acid storage in adipose tissue and secretion of adipokines, rosiglitazone significantly enhances insulin sensitivity, making it extensively utilized in metabolic and diabetes research, particularly type II diabetes studies.
- 1. Yuan Gao, cai zhang, et al. "The Novel Loss-of-function Arg212Trp Mutation in PPARG Causes Familial Partial Lipodystrophy Type 3." Research Square. 09 May, 2024
- 2. WeijieSuna, XiaoyuDuana, et al. "Adipogenic activity of 2-ethylhexyl diphenyl phosphate via peroxisome proliferator-activated receptor γ pathway." Science of The Total Environment. Available online 18 November 2019, 134810.
- 3. LianyingZhangab, WeijieSuna, et al. "Promoting differentiation and lipid metabolism are the primary effects for DINP exposure on 3T3-L1 preadipocytes." Environmental Pollution. Available online 13 September 2019, 113154.
| Storage | Store at -20°C |
| M.Wt | 357.43 |
| Cas No. | 122320-73-4 |
| Formula | C18H19N3O3S |
| Synonyms | Brl-49653, Brl 49653 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥17.85 mg/mL in DMSO |
| Chemical Name | 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Non-small cell lung carcinoma (NSCLC) cells (H1792 and H1838) |
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Preparation method |
The solubility of this compound in DMSO is >17.9 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37°C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
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Reacting condition |
10 μmol/L, 48 hours |
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Applications |
Rosiglitazone reduced the phosphorylation of Akt and increased phosphatase and tensin homologue (PTEN) protein expression in non–small cell lung carcinoma (NSCLC) cells (H1792 and H1838), and this was associated with inhibition of NSCLC cell proliferation. Rosiglitazone increased the phosphorylation of AMP-activated protein kinase α (AMPKα), a downstream kinase target for LKB1, whereas it decreased phosphorylation of p70 ribosomal protein S6 kinase (p70S6K), a downstream target of mammalian target of rapamycin (mTOR). |
| Animal experiment [2]: | |
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Animal models |
C57/BL6 mice |
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Dosage form |
8 mg/kg per day |
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Application |
In C57/BL6 mice underwent femoral angioplasty, treatment with rosiglitazone (8 mg/kg per day) attenuated neointimal formation. In a BM transplantation model, Rosiglitazone caused a 6-fold increase in colony formation by human endothelial progenitor cells, promoted the differentiation of APCs toward the endothelial lineage in mouse BM in vivo and in human peripheral blood in vitro, and inhibited the differentiation toward the smooth muscle cell lineage. Within the neointima, rosiglitazone stimulated APCs to differentiate into mature endothelial cells and caused earlier reendothelialization. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1] Han S W, Roman J. Rosiglitazone suppresses human lung carcinoma cell growth through PPARγ-dependent and PPARγ-independent signal pathways [J]. Molecular cancer therapeutics, 2006, 5 (2): 430-437. [2] Wang C H, Ciliberti N, Li S H, et al. Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage [J]. Circulation, 2004, 109 (11): 1392-1400. |
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Quality Control & MSDS
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Chemical structure
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